Basu Arijit, Kunduru Konda Reddy, Abtew Ester, Domb Abraham J
†Institute for Drug Research, School of Pharmacy-Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel 91120.
‡Department of Pharmaceutical Sciences and Technology, Birla Institute of Technology, Mesra, 835215, India.
Bioconjug Chem. 2015 Aug 19;26(8):1396-412. doi: 10.1021/acs.bioconjchem.5b00242. Epub 2015 Jul 20.
Polysaccharides contain different functional groups (such as hydroxyl, amino, carboxylic acid, aldehydes) that make them ideal for conjugation. They are biodegradable, biocompatible, and hydrophilic. Polysaccharide conjugates have been used in drug, gene, and macromolecule delivery, tissue engineering, and other biomedical applications. Polysaccharide conjugates have also been used primarily for solubilization and controlled release of hydrophobic moieties. The advent of nanotechnology, gene therapy, and tissue engineering influenced the way these conjugates are now used. Modern day conjugates are modulated to be thermoresponsive, pH-responsive, photoresponsive, or target-specific (receptor mediated targeting). This Review briefly introduces different polysaccharides followed by different synthetic strategies used for conjugation; finally, recent applications were compiled.
多糖含有不同的官能团（如羟基、氨基、羧酸、醛基），这使其成为共轭的理想选择。它们具有生物可降解性、生物相容性和亲水性。多糖共轭物已用于药物、基因和大分子递送、组织工程及其他生物医学应用。多糖共轭物还主要用于疏水性部分的增溶和控释。纳米技术、基因治疗和组织工程的出现影响了这些共轭物目前的使用方式。现代共轭物被调控为具有热响应性、pH响应性、光响应性或靶向特异性（受体介导靶向）。本综述简要介绍了不同的多糖，随后介绍了用于共轭的不同合成策略；最后，汇编了近期的应用。
