a Department of Pharmaceutical Engineering , College of Biology & Pharmacy, Yulin Normal University , Yulin , P. R. China.
b Guangxi Key Laboratory of Farm Products Processing (Cultivation Base) , Yulin Normal University , Yulin , P. R. China.
Nat Prod Res. 2017 Apr;31(7):829-834. doi: 10.1080/14786419.2016.1250085. Epub 2016 Oct 26.
Two new lignan compounds, 5'-allyl-2,2'-dihydroxy-[1,1'-biphenyl]-5-carboxylic acid (1) and 4,4'-diallyl-[1,1'-biphenyl]-2,2'-diol (2), together with four known compounds (3-6), were isolated from the barks of Sassafras tzumu. The new compounds were determined by NMR (H and C NMR, HSQC, HMBC, H-H COSY, NOESY/ROESY), and MS analysis. Compounds 1-3 showed potent AChE inhibitory activities, with IC values of 2.00, 1.81 and 1.91 μM, respectively.
两种新的木脂素化合物，5'-烯丙基-2,2'-二羟基-[1,1'-联苯]-5-羧酸（1）和 4,4'-二烯丙基-[1,1'-联苯]-2,2'-二醇（2），以及四种已知化合物（3-6），从枫香树皮中分离得到。新化合物通过 NMR（H 和 C NMR、HSQC、HMBC、H-H COSY、NOESY/ROESY）和 MS 分析确定。化合物 1-3 表现出很强的 AChE 抑制活性，IC 值分别为 2.00、1.81 和 1.91 μM。
