Malik Abdul, Anis Itrat, Khan Sher Bahadar, Ahmed Ejaz, Ahmed Zaheer, Nawaz Sarfraz Ahmad, Choudhary Muhammad Iqbal
International Centre for Chemical Sciences, H.E.J. Research Institute of Chemistry, University of Karachi, Karachi-75270, Pakistan.
Chem Pharm Bull (Tokyo). 2004 Nov;52(11):1269-72. doi: 10.1248/cpb.52.1269.
Two new lignans trivially named negundins A (1) and B (2), were isolated along with (+)-diasyringaresinol (3), (+)-lyoniresinol (4), vitrofolal E (5) and vitrofolal F (6), reported for the first time from this species. The structures of the new compounds were established through spectral studies. Compound 2 showed potent inhibitory activity against lipoxygenase enzyme, while 5 showed moderate activity against butyryl-cholinesterase.
从该物种中首次分离出两种新的木脂素，分别命名为negundins A（1）和B（2），同时还分离出（+）-二紫丁香树脂醇（3）、（+）-续随子醇（4）、体外叶醇E（5）和体外叶醇F（6）。通过光谱研究确定了新化合物的结构。化合物2对脂氧合酶显示出强效抑制活性，而化合物5对丁酰胆碱酯酶显示出中等活性。
