精神分裂症易感基因 ZNF804A 可增加罹患主要心境障碍的风险。
The schizophrenia susceptibility gene ZNF804A confers risk of major mood disorders.
机构信息
a Mental Health Institute of the Second Xiangya Hospital, Central South University , Changsha , Hunan , China.
b Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province , Kunming Institute of Zoology , Kunming , Yunnan , China.
出版信息
World J Biol Psychiatry. 2017 Oct;18(7):557-562. doi: 10.1080/15622975.2016.1252466. Epub 2016 Nov 21.
OBJECTIVES
Genome-wide association studies (GWAS) followed by independent replications suggest that ZNF804A is a risk gene for schizophrenia (SCZ), considering the substantial genetic overlap between SCZ and major mood disorders (e.g., bipolar disorder (BPD) and major depressive disorder (MDD)).
METHODS
We collected the data of two ZNF804A single-nucleotide polymorphisms (SNPs rs1344706 and rs7597593) from European and Asian populations to perform systematic meta-analyses with major mood disorders in a total of 65,240 subjects.
RESULTS
Meta-analysis showed that rs1344706 and rs7597593 were both associated with major mood disorders as well as diagnosis of either BPD or MDD, although neither of the analyses achieved a genome-wide level of statistical significance.
CONCLUSIONS
Our data provide evidence for the genetic involvement of ZNF804A SNPs in the susceptibility of major mood disorders, but further replication analyses in larger samples are necessary.
目的
全基因组关联研究（GWAS）随后的独立复制表明，ZNF804A 是精神分裂症（SCZ）的风险基因，考虑到 SCZ 与主要心境障碍（如双相情感障碍（BPD）和重性抑郁障碍（MDD））之间存在大量遗传重叠。
方法
我们从欧洲和亚洲人群中收集了两个 ZNF804A 单核苷酸多态性（SNP rs1344706 和 rs7597593）的数据，对总计 65240 名受试者的主要心境障碍进行了系统的荟萃分析。
结果
荟萃分析表明，rs1344706 和 rs7597593 均与主要心境障碍以及 BPD 或 MDD 的诊断相关，尽管这些分析均未达到全基因组水平的统计学意义。
结论
我们的数据为 ZNF804A SNP 参与主要心境障碍易感性提供了证据，但需要在更大样本中进行进一步的复制分析。
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