Rahman Shamma S, Boesen Erika I
Department of Cellular and Integrative Physiology, University of Nebraska Medical Center, Omaha, Nebraska.
Department of Cellular and Integrative Physiology, University of Nebraska Medical Center, Omaha, Nebraska
Am J Physiol Renal Physiol. 2016 Dec 1;311(6):F1341-F1345. doi: 10.1152/ajprenal.00488.2016. Epub 2016 Oct 26.
Body water balance is critical to survival and, therefore, very tightly regulated by the hypothalamus and kidney. A key mechanism involved in this process, the arginine vasopressin-mediated phosphorylation and apical membrane insertion of aquaporin 2 in the collecting duct, has been extensively studied; however, with the increased availability of conditional knockout animals, several novel collecting duct proteins have recently been implicated in water homeostasis. In this Mini-Review, we briefly discuss these novel proteins and their roles in the regulation of water homeostasis.
机体水平衡对生存至关重要，因此受到下丘脑和肾脏的严格调控。这一过程涉及的一个关键机制，即精氨酸加压素介导的集合管中水通道蛋白2的磷酸化及顶端膜插入，已得到广泛研究；然而，随着条件性基因敲除动物的可得性增加，最近有几种新的集合管蛋白被认为与水平衡有关。在本微型综述中，我们简要讨论这些新蛋白及其在水平衡调节中的作用。
