刺激麻醉犬左心房感受器对冠状动脉血流量的影响。
The effect of stimulation of left atrial receptors on coronary blood flow in anaesthetized dogs.
作者信息
Drinkhill M J, Kaye D, Mary D A
机构信息
Department of Cardiovascular Studies, University of Leeds.
出版信息
J Physiol. 1989 Jan;408:45-56. doi: 10.1113/jphysiol.1989.sp017445.
Abstract
- To determine whether stimulation of atrial receptors reflexly affects coronary blood flow, experiments were performed in seven dogs anaesthetized with alpha-chloralose. The left upper and middle pulmonary vein-atrial junctions and atrial appendage were stretched by distension of small balloons. Coronary blood flow was measured using an electromagnetic flowmeter positioned around the origin of the left anterior descending or circumflex coronary artery. 2. Following prevention of the reflex increase in heart rate by atrial pacing or propranolol, distension of the small balloons was shown to result in a decrease in mean coronary blood flow. 3. Cooling of the cervical vagosympathetic nerve trunks to 9 degrees C abolished the response of a decrease in mean coronary blood flow to distension of the balloons. 4. The response of a decrease in mean coronary blood flow was abolished by bretylium tosylate. 5. It was shown that a decrease in mean coronary blood flow occurred in response to stimulation of left atrial receptors, and that this decrease was reflex in nature. This reflex response is likely to involve atrial receptors discharging into afferent myelinated vagal fibres, and the efferent limb involves cardiac sympathetic pathways.
摘要
- 为了确定刺激心房感受器是否会反射性地影响冠状动脉血流量，对7只用α-氯醛糖麻醉的犬进行了实验。通过小气球扩张来拉伸左上和中肺静脉-心房交界处以及心耳。使用置于左前降支或回旋支冠状动脉起始处周围的电磁流量计测量冠状动脉血流量。2. 在通过心房起搏或普萘洛尔预防心率反射性增加后，小气球扩张显示会导致平均冠状动脉血流量减少。3. 将颈迷走交感神经干冷却至9摄氏度可消除平均冠状动脉血流量对气球扩张的减少反应。4. 托西溴苄铵可消除平均冠状动脉血流量减少的反应。5. 结果表明，刺激左心房感受器会导致平均冠状动脉血流量减少，且这种减少本质上是反射性的。这种反射反应可能涉及心房感受器向传入有髓迷走纤维放电，传出支涉及心脏交感神经通路。
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