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犬左心房扩张引起血浆血管加压素降低所涉及的心房受体。

The atrial receptors responsible for the decrease in plasma vasopressin caused by distension of the left atrium in the dog.

作者信息

Bennett K L, Linden R J, Mary D A

出版信息

Q J Exp Physiol. 1984 Jan;69(1):73-81. doi: 10.1113/expphysiol.1984.sp002797.

DOI:10.1113/expphysiol.1984.sp002797
PMID:6718685
Abstract

In dogs anaesthetized with chloralose, the effects of cooling the cervical vagi on the reflex decrease in plasma concentration of vasopressin, caused by distension of a large balloon in the lumen of the left atrium, were examined. Distension of the balloon in ten dogs with the vagi at 37 degrees C resulted in a decrease in plasma concentration of vasopressin and, as before, an increase in urine flow. The responses were not significantly affected by cooling to 16-18 degrees C but were abolished at 9 degrees C. At 16-18 degrees C the increase in activity in myelinated vagal afferent fibres is largely unchanged and at 9 degrees C is abolished (Kappagoda, Linden & Sivananthan, 1979; Sivananthan, Kappagoda & Linden, 1981). It is concluded that the decrease in plasma concentration of vasopressin during distension of the left atrium is mediated by the Paintal-type atrial receptors with myelinated vagal afferent fibres.

摘要

在用氯醛糖麻醉的犬中,研究了冷却颈迷走神经对左心房腔内大球囊扩张引起的血管升压素血浆浓度反射性降低的影响。在10只迷走神经处于37℃的犬中,球囊扩张导致血管升压素血浆浓度降低,且如前所述,尿流量增加。冷却至16 - 18℃时,这些反应未受到显著影响,但在9℃时反应消失。在16 - 18℃时,有髓迷走传入纤维的活动增加基本未变,而在9℃时则消失(卡帕戈达、林登和西瓦南坦,1979年;西瓦南坦、卡帕戈达和林登,1981年)。得出的结论是,左心房扩张期间血管升压素血浆浓度的降低是由具有有髓迷走传入纤维的潘塔尔型心房受体介导的。

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Q J Exp Physiol. 1984 Jan;69(1):73-81. doi: 10.1113/expphysiol.1984.sp002797.
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