Saute R L, Soder R B, Alves Filho J O, Baldisserotto M, Franco A R
PUCRS, Brain Institute (BraIns), Porto Alegre, Brazil.
PUCRS, Faculdade de Medicina, Porto Alegre, Brazil.
Pediatr Obes. 2018 Jan;13(1):74-77. doi: 10.1111/ijpo.12190. Epub 2016 Oct 27.
There has been a growing amount of evidence indicating that excess visceral fat is associated with alterations in brain structure and function, including brain cortical thinning in adults.
This study aims to investigate the relationship between brain cortical thickness with obesity assessments, in adolescents.
In this study, we measured three different obesity assessments within an adolescent population (aged 15 - 18 years): body mass index (BMI), visceral fat ratio measured with an MRI and hepatorenal gradient measured with an ultrasound. Volunteers also underwent an MRI scan to measure brain structure.
Results indicated that there was no relationship of BMI or hepatorenal gradient with brain cortical dimensions. However, there was a significant association between visceral fat ratio and an increase of cortical thickness throughout the brain.
These results suggest that visceral fat, but not BMI, is correlated with cortical thickening in adolescence.
越来越多的证据表明，内脏脂肪过多与大脑结构和功能的改变有关，包括成年人的脑皮质变薄。
本研究旨在调查青少年脑皮质厚度与肥胖评估之间的关系。
在本研究中，我们在青少年人群（15 - 18岁）中测量了三种不同的肥胖评估指标：体重指数（BMI）、通过MRI测量的内脏脂肪比率和通过超声测量的肝肾梯度。志愿者还接受了MRI扫描以测量脑结构。
结果表明，BMI或肝肾梯度与脑皮质尺寸之间没有关系。然而，内脏脂肪比率与全脑皮质厚度增加之间存在显著关联。
这些结果表明，在青少年中，与皮质增厚相关的是内脏脂肪，而非BMI。
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