结直肠癌中的表观遗传生物标志物：前提与前景
Epigenetic biomarkers in colorectal cancer: premises and prospects.
作者信息
Zamani Mozhdeh, Hosseini Seyed Vahid, Mokarram Pooneh
机构信息
a Colorectal Research Center , Shiraz University of Medical Sciences , Shiraz , IR Iran.
b Gasteroenterohepatology Research Center , Nemazee Hospital, School of Medicine, Shiraz University of Medical Sciences , Shiraz , Iran.
出版信息
Biomarkers. 2018 Mar;23(2):105-114. doi: 10.1080/1354750X.2016.1252961. Epub 2016 Nov 10.
CONTEXT
Colorectal cancer is one of the most common cancers worldwide. Epigenetic alterations play an important role in the pathogenesis of the colorectal cancer.
OBJECTIVE
This review has focused on the most recent investigations, which has suggested potential epigenetic biomarkers in colorectal cancer.
METHODS
Evidences were achieved by searching online medical databases including Google scholar, Pubmed, Scopus and Science Direct.
RESULTS
Extensive studies have indicated that aberrant epigenetic modifications could serve as potential biomarkers for diagnosis, prognosis and prediction of colorectal cancer.
CONCLUSION
Advances in aberrant epigenetic modifications can open new avenues for exploration of reliable and robust biomarkers to improve the management of CRC patients.
背景
结直肠癌是全球最常见的癌症之一。表观遗传改变在结直肠癌的发病机制中起重要作用。
目的
本综述聚焦于最近的研究，这些研究提示了结直肠癌中潜在的表观遗传生物标志物。
方法
通过检索在线医学数据库获取证据，包括谷歌学术、PubMed、Scopus和科学Direct。
结果
大量研究表明，异常的表观遗传修饰可作为结直肠癌诊断、预后和预测的潜在生物标志物。
结论
异常表观遗传修饰的进展可为探索可靠且强大的生物标志物开辟新途径，以改善结直肠癌患者的管理。
Zotero 插件