Rahman F, Toshima Y, Kohno H, Kinoshita K, Tokunaga K
Department of Cardiovascular Surgery, Kyushu University School of Medicine, Fukuoka, Japan.
Jpn J Surg. 1989 May;19(3):346-50. doi: 10.1007/BF02471411.
The protective effects of trimetazidine on postischemic cardiac function were studied using isolated working rat heart preparations in which global ischemia had been induced with normothermic cardioplegia. After 30 minutes of reperfusion, following a 25 minutes period of ischemia, the addition of 10(-6) M or 10(-5) M trimetazidine to the cardioplegic solution significantly increased the per cent recovery of the cardiac output: from 54.8 +/- 4.1 per cent in the control group to 81.0 +/- 3.2 per cent (p less than 0.01) and 79.6 +/- 4.0 per cent (p less than 0.01), respectively, although lower (10(-7) M) or higher (10(-4) M) doses of the drug failed to result in any change. 10(-5) M trimetazidine also produced a significantly greater recovery of both the postischemic aortic flow: from 47.8 +/- 4.9 per cent to 72.2 +/- 3.8 per cent (p less than 0.01) and coronary flow: from 80.6 +/- 2.9 per cent to 105.2 +/- 6.3 per cent (p less than 0.002). However, trimetazidine did not influence the recovery of either aortic pressure or heart rate. These results suggest that trimetazidine does give some protection to the heart during ischemia and reperfusion.
使用离体工作大鼠心脏标本研究了曲美他嗪对缺血后心功能的保护作用，该标本采用常温心脏停搏诱导全心缺血。在25分钟缺血期后再灌注30分钟，向心脏停搏液中添加10(-6) M或10(-5) M曲美他嗪可显著提高心输出量的恢复百分比：分别从对照组的54.8±4.1%提高到81.0±3.2%（p<0.01）和79.6±4.0%（p<0.01），尽管较低（10(-7) M）或较高（10(-4) M）剂量的药物未能产生任何变化。10(-5) M曲美他嗪还使缺血后主动脉血流量和冠状动脉血流量的恢复显著增加：主动脉血流量从47.8±4.9%增加到72.2±3.8%（p<0.01），冠状动脉血流量从80.6±2.9%增加到105.2±6.3%（p<0.002）。然而，曲美他嗪对主动脉压或心率的恢复没有影响。这些结果表明，曲美他嗪在缺血和再灌注期间确实对心脏有一定的保护作用。
