Hamooda Mohamed, Fouad Hala, Galal Nermeen, Sewelam Nadia, Megahed Dina
Paediatrics Specialty Registrar, West Yorkshire and the Humber, United Kingdom.
Professor of Pediatrics, Faculty of Medicine, Cairo University, Cairo, Egypt.
Electron Physician. 2016 Sep 20;8(9):2897-2903. doi: 10.19082/2897. eCollection 2016 Sep.
The purpose of present study was to access the prevalence of anti-cyclic citrullinated peptide (anti-CCP) antibodies in children with Juvenile Idiopathic Arthritis (JIA), and to investigate the clinical significance and diagnostic value of the anti-CCP antibodies in correlation with age, sex & activity.
This case-control study was performed on 50 patients with JIA in addition to 40 sex and age-matched children as a control group. The participants were recruited from rheumatology Outpatient Clinic of Cairo University Specialized Pediatric Hospital. Patients were subjected to full history taking, clinical examination, routine laboratory investigations and x-rays on involved joints. Both patients and controls underwent assay of anti-CCP antibodies by AxSYM Anti-CCP IgG Microparticle Enzyme Immunoassay (MEIA) which is a semi-quantitative determination of the IgG class of autoantibodies specific to cyclic citrullinated peptide (CCP) in patients' serum or plasma. Data were analyzed using Mann-Whitney U test, ANOVA, and independent-samples t-test by SPSS version 15.
Anti-CCP positivity was identified amongst patients with JIA, particularly those JIA patients experiencing RF positive polyarticular disease onset. Above all, it is important that anti-CCP positivity and bone erosions, degree of joint damage, and ESR levels were significantly correlated.
Anti-CCP could be utilized as a valuable marker in the polyarticular form of JIA to direct early, and could be aggressive therapeutic intervention.
本研究旨在评估幼年特发性关节炎（JIA）患儿中抗环瓜氨酸肽（anti-CCP）抗体的患病率，并探讨anti-CCP抗体与年龄、性别及疾病活动度相关的临床意义和诊断价值。
本病例对照研究除纳入40名年龄和性别匹配的儿童作为对照组外，还纳入了50例JIA患者。参与者均来自开罗大学专科医院儿科风湿病门诊。对患者进行全面病史采集、临床检查、常规实验室检查及受累关节的X线检查。患者和对照组均采用AxSYM抗CCP IgG微粒酶免疫测定法（MEIA）检测anti-CCP抗体，该方法可半定量测定患者血清或血浆中针对环瓜氨酸肽（CCP）的IgG类自身抗体。数据采用SPSS 15.0软件进行Mann-Whitney U检验、方差分析和独立样本t检验。
在JIA患者中发现了anti-CCP阳性，尤其是那些RF阳性多关节型疾病起病的JIA患者。最重要的是，anti-CCP阳性与骨侵蚀、关节损伤程度及血沉水平显著相关。
anti-CCP可作为JIA多关节型的一个有价值的标志物，用于指导早期且积极的治疗干预。
