抗环瓜氨酸肽抗体在幼年特发性关节炎成年患者中的应用。

Anti-cyclic citrullinated peptide antibodies in adult patients with juvenile idiopathic arthritis.

机构信息

Evangelical University Hospital of Curitiba, Paraná, Brazil.

出版信息

J Clin Rheumatol. 2011 Dec;17(8):421-3. doi: 10.1097/RHU.0b013e31823a4d0a.

DOI:10.1097/RHU.0b013e31823a4d0a

PMID:22089992

Abstract

BACKGROUND

Antibodies to cyclic citrullinated peptide (anti-CCP) have been found in different proportions in the juvenile idiopathic arthritis (JIA) population. The majority of studies have been done in children or mixed population (children plus adults).

AIM

The objective of the study was to study the prevalence of anti-CCP in JIA adult patients.

METHODS

Anti-CCP3 was searched for in 49 adult patients with JIA and associated with clinical and demographics data. As comparisons, 156 patients with adult rheumatoid arthritis (RA) and 100 healthy volunteers were studied.

RESULTS

Nine patients (18.3%) were positive for anti-CCP3. All of them had the polyarthritis form. This antibody was more common in JIA than in control subjects (P = 0.0002) and less common in JIA than in adult RA patients (P < 0.0001), but the rheumatoid factor polyarticular form of JIA had the same prevalence as in adult RA patients (P = 0.33).In JIA patients, anti-CCP had a positive association with the presence of rheumatoid factor (P < 0.0001), worse functional status (P = 0.04), need for orthopedic surgery (P = 0.01), and later disease onset (P = 0.0007).

CONCLUSIONS

In adult patients with JIA, the prevalence of anti-CCP3 is 18%, and its presence may define a sample of patients with worse prognosis.

摘要

背景

抗环瓜氨酸肽（anti-CCP）抗体在幼年特发性关节炎（JIA）人群中存在不同比例。大多数研究是在儿童或混合人群（儿童加成人）中进行的。

目的

本研究旨在研究成年 JIA 患者中抗 CCP 的患病率。

方法

在 49 名成年 JIA 患者中搜索抗 CCP3，并与临床和人口统计学数据相关联。作为对照，研究了 156 名成年类风湿关节炎（RA）患者和 100 名健康志愿者。

结果

9 名患者（18.3%）抗 CCP3 阳性。他们均为多关节炎型。该抗体在 JIA 患者中比在对照组中更为常见（P = 0.0002），在 JIA 患者中比在成年 RA 患者中更为少见（P < 0.0001），但 JIA 多关节炎型类风湿因子的患病率与成年 RA 患者相同（P = 0.33）。在 JIA 患者中，抗 CCP 与类风湿因子的存在呈正相关（P < 0.0001），功能状态更差（P = 0.04），需要矫形手术（P = 0.01），以及发病较晚（P = 0.0007）。