Shahunja K M, Ahmed Tahmeed, Hossain Md Iqbal, Das Sumon Kumar, Faruque Abu Syeed Golam, Islam Md Munirul, Shahid Abu Sadat Mohammad Sayeem Bin, Das Jui, Sarker Mohammad Habibur Rahman, Chisti Mohammod Jobayer
International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh.
Glob Pediatr Health. 2016 Oct 18;3:2333794X16672528. doi: 10.1177/2333794X16672528. eCollection 2016.
To our knowledge, there are no data on the role of overweight and obesity in childhood pneumonia. We sought to determine that impact of overweight and obesity in such children. In this retrospective chart analysis, we enrolled hospitalized children aged 6 to 59 months in the Dhaka Hospital of the icddr,b, Bangladesh (International Centre for Diarrhoeal Disease Research, Bangladesh), from January 2010 to June 2014. Children with pneumonia having overweight and obesity (body mass index score [BMIZ] >2.00) constituted cases (n = 25), and those who had pneumonia without overweight and obesity (BMIZ -2.00 to 2.00) constituted controls (n = 75). Controls were 3-fold of the cases and were randomly selected. Demographic, clinical, and laboratory data of the cases and the controls were compared. The cases more often had diarrhea and dehydration (36% vs 12%, = .013), hypoxemia (SpO < 90% in room air; 28% vs 7%, = .009) on admission, and required to change antibiotics (32% vs 11%, = .023) during hospitalization compared to the controls. However, in logistic regression analysis the cases were independently associated with diarrhea ( < .001) and hypoxemia ( = .024) on admission. Our data suggest that overweight and obesity in children with pneumonia is prone to be associated with hypoxemia on admission, which may guide clinicians in promptly managing pneumonia in order to evade its ramification in such children. However, future research with larger samples is imperative to consolidate or refute our observation.
据我们所知,尚无关于超重和肥胖在儿童肺炎中作用的数据。我们试图确定超重和肥胖对这类儿童的影响。在这项回顾性图表分析中,我们纳入了2010年1月至2014年6月期间在孟加拉国腹泻病研究国际中心(icddr,b)达卡医院住院的6至59个月大的儿童。患有超重和肥胖(体重指数评分[BMIZ]>2.00)的肺炎儿童构成病例组(n = 25),而患有肺炎但无超重和肥胖(BMIZ -2.00至2.00)的儿童构成对照组(n = 75)。对照组人数是病例组的3倍,且为随机选取。对病例组和对照组的人口统计学、临床和实验室数据进行了比较。与对照组相比,病例组入院时更常出现腹泻和脱水(36%对12%,P = .013)、低氧血症(室内空气下SpO<90%;28%对7%,P = .009),且住院期间需要更换抗生素(32%对11%,P = .023)。然而,在逻辑回归分析中,病例组与入院时的腹泻(P<.001)和低氧血症(P = .024)独立相关。我们的数据表明,肺炎儿童中的超重和肥胖易与入院时的低氧血症相关,这可能指导临床医生及时处理肺炎,以避免其在这类儿童中产生不良后果。然而,未来需要更大样本的研究来巩固或反驳我们的观察结果。