Kalinina A M, Chazova L V, Pavlova L I, Shchepkin V V, Panfilova O A
Kardiologiia. 1989 Jun;29(6):28-32.
In a population of males aged 40-59 years, a routine epidemiological survey was performed, which was followed by a 5-year follow-up to examine the mortality rates and incidence of myocardial infarction and stroke treated by an active prophylactic measure program (Group 1) and conventional regimen (Group 2). The total cholesterol levels of 260 mg/dl or more were found to be of highly prognostic value to death from all causes, largely cardiovascular diseases, to development of myocardial infarction, stroke, and to higher risk of fatal cases of the diseases. It was ascertained that it was difficult to modify the dietary habits in subjects of mature age. By the end of the fifth follow-up year, the examined patients from Group 1 showed a reduction in the mean level of total cholesterol and hypercholesterolemia rates, following by a decrease in total and cardiovascular mortality by 6.5 and 5.7%, respectively, the incidence of myocardial infarction and stroke and the risk of death from these complications becoming lower.
在40至59岁的男性人群中，开展了一项常规流行病学调查，随后进行了为期5年的随访，以检查采用积极预防措施方案（第1组）和传统治疗方案（第2组）治疗的心肌梗死和中风的死亡率及发病率。发现总胆固醇水平达到260毫克/分升及以上对各种原因导致的死亡、主要是心血管疾病导致的死亡、心肌梗死和中风的发生以及这些疾病致命病例的更高风险具有高度预后价值。已确定在成年受试者中改变饮食习惯很困难。到第五次随访年末，第1组接受检查的患者总胆固醇平均水平和高胆固醇血症发生率有所降低，随后总死亡率和心血管死亡率分别降低了6.5%和5.7%，心肌梗死和中风的发病率以及这些并发症导致的死亡风险降低。
