Steubl Dominik, Block Matthias, Herbst Victor, Schlumberger Wolfgang, Nockher Andreas, Angermann Susanne, Schmaderer Christoph, Heemann Uwe, Renders Lutz, Scherberich Jürgen
a Department of Nephrology, Klinikum rechts der Isar , Technische Universität , München , Germany.
b Research&Development Department, Euroimmun Medizinische Labordiagnostika AG , Lübeck , Germany.
Biomarkers. 2017 Mar;22(2):171-177. doi: 10.1080/1354750X.2016.1252957. Epub 2016 Nov 14.
Test the ability of serum uromodulin concentrations 1-3 months after renal transplantation to predict all-cause mortality (ACM) and graft loss (GL) in 91 patients.
uromodulin predicted GL equivalently to the other markers studied: the risk for GL was reduced by 0.21 per one standard deviation (SD) increase (cystatin C: hazard ratio [HR] 4.57, creatinine: HR 4.53, blood-urea-nitrogen [BUN]: HR 2.50, estimated glomerular filtration rate [eGFR]: HR 0.10). In receiver-operating-characteristic (ROC) analysis, uromodulin predicted GL with an area-under-the curve of 0.782 at an optimal cut-off (OCO) of 24.0 ng/ml with a sensitivity of 90.0% and a specificity of 70.2%.
Serum uromodulin predicted GL equivalently compared to conventional biomarkers of glomerular filtration.
检测91例肾移植患者肾移植后1至3个月时血清尿调节素浓度预测全因死亡率（ACM）和移植物丢失（GL）的能力。
尿调节素对移植物丢失的预测能力与所研究的其他标志物相当：每增加一个标准差（SD），移植物丢失风险降低0.21（胱抑素C：风险比[HR]4.57，肌酐：HR 4.53，血尿素氮[BUN]：HR 2.50，估计肾小球滤过率[eGFR]：HR 0.10）。在受试者工作特征（ROC）分析中，尿调节素预测移植物丢失的曲线下面积为0.782，最佳截断值（OCO）为24.0 ng/ml，敏感性为90.0%，特异性为70.2%。
与肾小球滤过的传统生物标志物相比，血清尿调节素对移植物丢失的预测能力相当。
