血清尿调节蛋白可预测肾移植受者的移植肾失败。

Serum uromodulin predicts graft failure in renal transplant recipients.

作者信息

Steubl Dominik, Block Matthias, Herbst Victor, Schlumberger Wolfgang, Nockher Andreas, Angermann Susanne, Schmaderer Christoph, Heemann Uwe, Renders Lutz, Scherberich Jürgen

机构信息

a Department of Nephrology, Klinikum rechts der Isar , Technische Universität , München , Germany.

b Research&Development Department, Euroimmun Medizinische Labordiagnostika AG , Lübeck , Germany.

出版信息

Biomarkers. 2017 Mar;22(2):171-177. doi: 10.1080/1354750X.2016.1252957. Epub 2016 Nov 14.

DOI:10.1080/1354750X.2016.1252957

PMID:27790922

Abstract

OBJECTIVE AND METHODS

Test the ability of serum uromodulin concentrations 1-3 months after renal transplantation to predict all-cause mortality (ACM) and graft loss (GL) in 91 patients.

RESULTS

uromodulin predicted GL equivalently to the other markers studied: the risk for GL was reduced by 0.21 per one standard deviation (SD) increase (cystatin C: hazard ratio [HR] 4.57, creatinine: HR 4.53, blood-urea-nitrogen [BUN]: HR 2.50, estimated glomerular filtration rate [eGFR]: HR 0.10). In receiver-operating-characteristic (ROC) analysis, uromodulin predicted GL with an area-under-the curve of 0.782 at an optimal cut-off (OCO) of 24.0 ng/ml with a sensitivity of 90.0% and a specificity of 70.2%.

CONCLUSION

Serum uromodulin predicted GL equivalently compared to conventional biomarkers of glomerular filtration.

摘要

目的与方法

检测91例肾移植患者肾移植后1至3个月时血清尿调节素浓度预测全因死亡率（ACM）和移植物丢失（GL）的能力。

结果

尿调节素对移植物丢失的预测能力与所研究的其他标志物相当：每增加一个标准差（SD），移植物丢失风险降低0.21（胱抑素C：风险比[HR]4.57，肌酐：HR 4.53，血尿素氮[BUN]：HR 2.50，估计肾小球滤过率[eGFR]：HR 0.10）。在受试者工作特征（ROC）分析中，尿调节素预测移植物丢失的曲线下面积为0.782，最佳截断值（OCO）为24.0 ng/ml，敏感性为90.0%，特异性为70.2%。