用于抗生素改进的纳米结构功能化：一种跨学科方法。

Functionalization of nanostructures for antibiotic improvement: an interdisciplinary approach.

作者信息

Saúde Acm, Franco O L

机构信息

Centro de Análises Proteômicas e Bioquímicas, Pós-Graduação em Ciências Genômicas e Biotecnologia, Universidade Católica de Brasília, Brasília, DF, Brasil.

Universidade de Brasília - UNB. Campus Universitário Darcy Ribeiro, S/N - Asa Norte - CEP: 70790-160 Brasília, DF, Brasil.

出版信息

Ther Deliv. 2016 Nov;7(11):761-771. doi: 10.4155/tde-2016-0047. Epub 2016 Oct 28.

DOI:10.4155/tde-2016-0047

PMID:27790945

Abstract

The resistance of infectious bacteria to current antibiotics is a worldwide problem caused, partially, by the overuse of antimicrobials. The use of nanotechnology as an innovative tool against bacterial infections provides a range of methodologies to redesign old antibiotics for novel and remarkable new strategies. Thus, functionalized antibiotics present structures with improved bioavailability, low toxicity and specificity to bacterial membrane. In this context, this review will describe the use of nanotechnology as an innovative tool to functionalize antibiotics. In addition, the importance of the interdisciplinary context to understand, develop and apply these systems as an innovative tool for drug development and improvement is discussed.

摘要

传染性细菌对当前抗生素产生耐药性是一个全球性问题，部分原因是抗菌药物的过度使用。将纳米技术用作对抗细菌感染的创新工具，提供了一系列方法来重新设计旧抗生素，以实现新颖且卓越的新策略。因此，功能化抗生素具有生物利用度提高、低毒性以及对细菌膜具有特异性的结构。在此背景下，本综述将描述纳米技术作为一种使抗生素功能化的创新工具的应用。此外，还讨论了跨学科背景对于理解、开发和应用这些系统作为药物开发和改进的创新工具的重要性。