Diab Roudayna, Khameneh Bahman, Joubert Olivier, Duval Raphael
SRSMC, UMR 7565, CNRSUniversite de Lorraine, Faculte de Pharmacie, 5, rue Albert Lebrun, BP 80403, 54001 Nancy Cedex, France.
Curr Pharm Des. 2015;21(28):4095-105. doi: 10.2174/138161282128150922175445.
Nanotechnology has been revealed as a fundamental approach for antibiotics delivery. In this paper, recent findings demonstrating the superiority of nanocarried-antibiotics over "naked" ones and the ways by which nanoparticles can help to overwhelm bacterial drug resistance are reviewed. The second part of this paper sheds light on nanoparticle-bacterium interaction patterns. Finally, key factors affecting the effectiveness of nanoparticles interactions with bacteria are discussed.
纳米技术已被证明是抗生素递送的一种基本方法。本文综述了近期的研究结果，这些结果表明纳米载抗生素相对于“裸”抗生素的优越性，以及纳米颗粒有助于克服细菌耐药性的方式。本文的第二部分阐述了纳米颗粒与细菌的相互作用模式。最后，讨论了影响纳米颗粒与细菌相互作用有效性的关键因素。
