钯(0)催化的β-萘酚分子间芳构化去芳构化反应。
Palladium(0)-Catalyzed Intermolecular Arylative Dearomatization of β-Naphthols.
机构信息
State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Lu, Shanghai, 200032, China.
出版信息
Angew Chem Int Ed Engl. 2016 Nov 21;55(48):15137-15141. doi: 10.1002/anie.201608724. Epub 2016 Oct 28.
PMID:27791314
Abstract
The first Pd -catalyzed intermolecular arylative dearomatization of β-naphthols with aryl halides is described. It was found that Q-Phos could facilitate the palladium-catalyzed cross-coupling-type dearomatization of β-naphthols, while avoiding O-arylation, to construct 2-naphthalenones in excellent yields and with high chemoselectivity.
摘要
首次报道了钯催化的β-萘酚与芳基卤化物的分子间芳基化去芳构化反应。研究发现，Q-Phos 能够促进钯催化的交叉偶联型β-萘酚去芳构化，同时避免 O-芳基化，以优异的收率和高化学选择性构建 2-萘满酮。
Zotero 插件