β-萘酚的不对称去芳构化通过双功能硫脲催化的迈克尔反应实现。
Asymmetric Dearomatization of β-Naphthols through a Bifunctional-Thiourea-Catalyzed Michael Reaction.
机构信息
State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Lu, Shanghai 200032 (China) http://shuliyou.sioc.ac.cn/
State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Lu, Shanghai 200032 (China) http://shuliyou.sioc.ac.cn/.
出版信息
Angew Chem Int Ed Engl. 2015 Dec 1;54(49):14929-32. doi: 10.1002/anie.201507998. Epub 2015 Oct 14.
An intermolecular asymmetric dearomatization reaction of β-naphthols with nitroethylene through a chiral-thiourea-catalyzed Michael reaction is described. Enantioenriched functionalized β-naphthalenones with an all-carbon quaternary stereogenic center could thus be easily constructed from simple naphthol derivatives in good yields and excellent enantioselectivity (up to 79% yield, 98% ee).
描述了一种通过手性硫脲催化的迈克尔加成反应实现β-萘酚与硝基乙烯的分子间不对称去芳构化反应。通过简单的萘酚衍生物可以高产率和优异的对映选择性（高达 79%的产率，98%ee）轻松构建具有全碳季立体中心的手性官能化β-萘满酮。
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