Farrell Eric, Heffron Cynthia, Murphy Matthew, O'Leary Gerard, Sheahan Patrick
School of Medicine, University College Cork, Cork, Ireland, United Kingdom.
Department of Pathology, Cork University Hospital, Cork, Ireland, United Kingdom.
Head Neck. 2017 Jan;39(1):122-127. doi: 10.1002/hed.24544. Epub 2016 Oct 28.
The purpose of this study was to investigate the impact of lymphocytic thyroiditis on incidence of incidental thyroid cancers.
We conducted a retrospective review of 713 consecutive patients who underwent thyroidectomies. Incidental thyroid cancer was defined as an unexpected cancer discovered on pathological examination outside the index nodule undergoing preoperative cytology.
We excluded 65 cases because of preoperative diagnosis of thyroid cancer, and 68 because of nonincidental cancer within the index nodule. Among the remaining 580 cases, there were 43 cases (7.4%) of incidental thyroid cancers. Incidental thyroid cancers were significantly associated with moderate/severe lymphocytic thyroiditis (relative risk = 2.5; p = .03). Sixteen of 56 patients with moderate/severe lymphocytic thyroiditis had Graves' disease, none of whom had incidental thyroid cancer. The risk of incidental thyroid cancer associated with moderate/severe lymphocytic thyroiditis was significantly higher in non-Graves' than patients with Graves' disease (p = .05).
The risk of incidental thyroid cancer is significantly increased in patients with moderate/severe lymphocytic thyroiditis. Moderate/severe lymphocytic thyroiditis associated with Graves' disease seems to have a lower risk of incidental thyroid cancer. © 2016 Wiley Periodicals, Inc. Head Neck 39: 122-127, 2017.
本研究旨在调查淋巴细胞性甲状腺炎对意外甲状腺癌发病率的影响。
我们对713例连续接受甲状腺切除术的患者进行了回顾性研究。意外甲状腺癌定义为在术前细胞学检查的索引结节以外的病理检查中发现的意外癌症。
我们排除了65例术前诊断为甲状腺癌的病例，以及68例索引结节内非意外癌症的病例。在其余580例病例中，有43例（7.4%）为意外甲状腺癌。意外甲状腺癌与中度/重度淋巴细胞性甲状腺炎显著相关（相对风险=2.5；p=0.03）。56例中度/重度淋巴细胞性甲状腺炎患者中有16例患有格雷夫斯病，其中无一例患有意外甲状腺癌。非格雷夫斯病患者中与中度/重度淋巴细胞性甲状腺炎相关的意外甲状腺癌风险显著高于格雷夫斯病患者（p=0.05）。
中度/重度淋巴细胞性甲状腺炎患者意外甲状腺癌的风险显著增加。与格雷夫斯病相关的中度/重度淋巴细胞性甲状腺炎似乎意外甲状腺癌风险较低。©2016威利期刊公司。头颈39:122 - 127，2017。
