MacIntosh Bradley J, Shirzadi Zahra, Scavone Antonette, Metcalfe Arron Ws, Islam Alvi H, Korczak Daphne, Goldstein Benjamin I
Heart and Stroke Foundation Canadian Partnership for Stroke Recovery, Sunnybrook Research Institute, Toronto, ON, Canada; Physical Sciences, Sunnybrook Research Institute, Toronto, ON, Canada; Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada.
Heart and Stroke Foundation Canadian Partnership for Stroke Recovery, Sunnybrook Research Institute, Toronto, ON, Canada; Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada.
J Affect Disord. 2017 Jan 15;208:205-213. doi: 10.1016/j.jad.2016.08.060. Epub 2016 Oct 21.
Cerebral blood flow (CBF) is altered in mood disorders but has not been examined among adolescents with bipolar disorder (BD). Similarly, little is known about the acute neurophysiologic effects of aerobic exercise in BD. We therefore compared CBF between adolescents with and without BD at rest and acutely following a single exercise session.
Thirty-one adolescents with BD and 20 age and sex-matched controls participated in this study. CBF magnetic resonance images (MRI) were acquired using arterial spin labeling at a baseline as well as 15 and 45min after a single 20-min session of recumbent cycling. Voxel-based CBF analyses compared groups at baseline and after exercise. Clinical, body mass index (BMI) and exercise-induced feelings inventory (EFI) data were examined for their influence on CBF findings.
Baseline CBF was increased in medial frontal and middle cingulate regions in BD compared to controls. Analysis of the acute CBF changes revealed pronounced exercise-related decreases in CBF in BD. Exercise-related feelings of exhaustion were associated with CBF changes in frontal but not parietal regions.
A single bout of moderate-intensity aerobic exercise reduced regional CBF to a greater extent in BD compared to controls; these time dependent CBF responses were associated with exercise-induced feelings of exhaustion.
情绪障碍患者的脑血流量（CBF）会发生改变，但双相情感障碍（BD）青少年的脑血流量尚未得到研究。同样，关于有氧运动对双相情感障碍的急性神经生理影响也知之甚少。因此，我们比较了患有和未患有双相情感障碍的青少年在静息状态下以及单次运动后即刻的脑血流量。
31名患有双相情感障碍的青少年以及20名年龄和性别匹配的对照组参与了本研究。使用动脉自旋标记技术在基线时以及在进行一次20分钟的卧式自行车运动后的15分钟和45分钟采集脑血流量磁共振成像（MRI）。基于体素的脑血流量分析比较了基线时和运动后的组间差异。检查了临床、体重指数（BMI）和运动诱发感觉量表（EFI）数据对脑血流量结果的影响。
与对照组相比，双相情感障碍患者额叶内侧和扣带回中部区域的基线脑血流量增加。对急性脑血流量变化的分析显示，双相情感障碍患者中与运动相关的脑血流量有明显下降。与运动相关的疲惫感与额叶而非顶叶区域的脑血流量变化有关。
与对照组相比，单次中等强度有氧运动使双相情感障碍患者的局部脑血流量下降幅度更大；这些随时间变化的脑血流量反应与运动诱发的疲惫感有关。
