Xu Meng, Chen Xiaoling, Chen Daiwen, Yu Bing, Huang Zhiqing
Key Laboratory for Animal Disease-Resistance Nutrition of China Ministry of Education, Institute of Animal Nutrition, Sichuan Agricultural University, Chengdu, Sichuan, P. R. China.
Oncotarget. 2017 Feb 7;8(6):10662-10674. doi: 10.18632/oncotarget.12891.
FoxO1, a member of the forkhead transcription factor forkhead box protein O (FoxO) family, is predominantly expressed in most muscle types. FoxO1 is a key regulator of muscle growth, metabolism, cell proliferation and differentiation. In the past two decades, many researches have indicated that FoxO1 is a negative regulator of skeletal muscle differentiation while contrasting opinions consider that FoxO1 is crucial for myoblast fusion. FoxO1 is expressed much higher in fast twitch fiber enriched muscles than in slow muscles and is also closely related to muscle fiber type specification. In this review, we summarize the molecular mechanisms of FoxO1 in the regulation of skeletal muscle differentiation and fiber type specification.
叉头转录因子叉头框蛋白O（FoxO）家族成员FoxO1在大多数肌肉类型中均有主要表达。FoxO1是肌肉生长、代谢、细胞增殖和分化的关键调节因子。在过去二十年中，许多研究表明FoxO1是骨骼肌分化的负调节因子，而相反的观点则认为FoxO1对成肌细胞融合至关重要。FoxO1在富含快肌纤维的肌肉中的表达远高于慢肌，并且也与肌纤维类型的特化密切相关。在本综述中，我们总结了FoxO1在调节骨骼肌分化和肌纤维类型特化中的分子机制。
