Peng Baozhou, Wang Yaning, Zhang Hongbo
Advanced Medical Technology Center, The First Affiliated Hospital, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China.
Key Laboratory for Stem Cells and Tissue Engineering, Ministry of Education, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China.
Cell Prolif. 2025 May;58(5):e13796. doi: 10.1111/cpr.13796. Epub 2024 Dec 26.
Mitochondria perform multiple functions within the cell, including the production of ATP and a great deal of metabolic intermediates, while also contributing to the cellular stress response. The majority of mitochondrial proteins are encoded by nuclear genomes, highlighting the importance of mitonuclear communication for sustaining mitochondrial homeostasis and functional. As a crucial part of the intracellular signalling network, mitochondria can impact stem cell fate determinations. Considering the essential function of stem cells in tissue maintenance, regeneration and aging, it is important to understand how mitochondria influence stem cell fate. This review explores the significant roles of mitonuclear communication and mitochondrial proteostasis, highlighting their influence on stem cells. We also examine how mitonuclear interactions contribute to cellular homeostasis, stem cell therapies, and the potential for extending lifespan.
线粒体在细胞内执行多种功能，包括三磷酸腺苷（ATP）的产生以及大量代谢中间产物的生成，同时也参与细胞应激反应。大多数线粒体蛋白由核基因组编码，这凸显了线粒体-细胞核通讯对于维持线粒体稳态和功能的重要性。作为细胞内信号网络的关键组成部分，线粒体能够影响干细胞的命运决定。鉴于干细胞在组织维持、再生和衰老过程中的重要功能，了解线粒体如何影响干细胞命运至关重要。本综述探讨了线粒体-细胞核通讯和线粒体蛋白质稳态的重要作用，强调了它们对干细胞的影响。我们还研究了线粒体-细胞核相互作用如何促进细胞稳态、干细胞治疗以及延长寿命的潜力。
