Thudt Marlene, Papadopoulos Nestoras, Monsefi Nadejda, Miskovic Aleksandra, Karimian-Tabrizi Afsaneh, Zierer Andreas, Moritz Anton
Division of Thoracic and Cardiovascular Surgery, Johann Wolfgang Goethe University, Frankfurt am Main, Germany.
Division of Thoracic and Cardiovascular Surgery, Johann Wolfgang Goethe University, Frankfurt am Main, Germany.
Ann Thorac Surg. 2017 Apr;103(4):1186-1192. doi: 10.1016/j.athoracsur.2016.08.082. Epub 2016 Oct 25.
Many techniques for repair of bicuspid aortic valves have been described and long-term results differ considerably. The current study evaluates our institutional results using the pericardial patch augmentation technique with the aim of increasing coaptation height.
From November 2002 through April 2015, 103 consecutive patients underwent aortic valve repair using pericardial patch augmentation for incompetent bicuspid aortic valve. Of them 26 were referred with an aortic valve regurgitation grade 1+ or 2+ and were excluded from the current report. The remaining 77 patients with a mean age of 42 ± 14 years and aortic valve regurgitation grade of 3+ or higher were included in this retrospective single-center study. The main step of operative technique is the partial correction of leaflet prolapse by leaflet plication and overcorrection of coaptation height augmenting the fused leaflet with an autologous pericardial patch. In 45 patients (58%) an isolated aortic valve repair was performed. The ascending aorta was dilated in 32 cases (42%), and the following procedures were used for correction: reduction aortoplasty (19 patients), the David procedure (11 patients), and ascending aortic replacement (2 patients). Long-term results were evaluated by echocardiography and standardized questionnaire. Mean follow-up was 4.9 ± 4.6 years.
There was no perioperative or 90-day mortality. Survival at 5 and 10 years was 96.1% and 93.5%, respectively. Freedom from reoperation at 5 and 10 years was 94.8% and 93.5%, respectively. At the latest echocardiographic follow-up, 94% of patients had none to trivial aortic regurgitation and 6% showed aortic regurgitation greater than or equal to 2°. Mean aortic gradients were 12.6 ± 9 mm Hg. One patients developed endocarditis 1 year after the procedure. There were no perioperative or long-term major neurologic events.
The pericardial patch augmentation technique provides reliable long-term competence of reconstructed bicuspid aortic valves and results in a low reoperation rate, with other valve related complications being rare.
已经描述了多种用于修复二叶式主动脉瓣的技术,且长期结果差异很大。本研究评估了我们机构采用心包补片扩大技术的结果,目的是增加瓣叶对合高度。
从2002年11月至2015年4月,103例连续患者因二叶式主动脉瓣功能不全接受了使用心包补片扩大的主动脉瓣修复术。其中26例患者转诊时主动脉瓣反流为1+或2+级,被排除在本报告之外。其余77例平均年龄为42±14岁、主动脉瓣反流为3+级或更高的患者纳入了这项回顾性单中心研究。手术技术的主要步骤是通过瓣叶折叠部分纠正瓣叶脱垂,并通过自体心包补片扩大融合瓣叶过度纠正对合高度。45例患者(58%)接受了单纯主动脉瓣修复术。32例(42%)升主动脉扩张,采用以下方法进行纠正:缩窄主动脉成形术(19例患者)、David手术(11例患者)和升主动脉置换术(2例患者)。通过超声心动图和标准化问卷评估长期结果。平均随访时间为4.9±4.6年。
围手术期或90天内无死亡。5年和10年生存率分别为96.1%和93.5%。5年和10年免于再次手术率分别为94.8%和93.5%。在最近一次超声心动图随访时,94%的患者无至微量主动脉反流,6%的患者主动脉反流≥2°。平均主动脉压差为12.6±9mmHg。1例患者术后1年发生心内膜炎。无围手术期或长期严重神经系统事件。
心包补片扩大技术为重建的二叶式主动脉瓣提供了可靠的长期功能,再次手术率低,其他瓣膜相关并发症罕见。