与自体卵母细胞体外受精妊娠相比，卵母细胞捐赠的子痫前期风险是否更高？
Does oocyte donation compared with autologous oocyte IVF pregnancies have a higher risk of preeclampsia?
作者信息
Tarlatzi Theoni B, Imbert Romain, Alvaro Mercadal Beatriz, Demeestere Isabelle, Venetis Christos A, Englert Yvon, Delbaere Anne
机构信息
Fertility Clinic, Department of Obstetrics and Gynecology, Erasme Hospital, Université Libre de Bruxelles, Brussels, Belgium.
Fertility Clinic, Department of Obstetrics and Gynecology, Erasme Hospital, Université Libre de Bruxelles, Brussels, Belgium.
出版信息
Reprod Biomed Online. 2017 Jan;34(1):11-18. doi: 10.1016/j.rbmo.2016.10.002. Epub 2016 Oct 14.
The aim of this study was to evaluate whether pregnancies resulting from oocyte donation have a higher risk of preeclampsia compared with pregnancies after IVF using autologous oocytes. Propensity score matching on maternal age and parity was carried out on a one to one basis, and a total of 144 singleton pregnancies resulting in delivery beyond 22 gestational weeks, achieved by oocyte donation, were compared with 144 pregnancies achieved through IVF and intracytoplasmic sperm injection with the use of autologous oocytes. All pregnancies were achieved after fresh embryo transfer. Obstetric and neonatal outcomes were compared for each pregnancy. Singleton pregnancies after oocyte donation were associated with a significantly higher risk for preeclampsia (OR 2.4, CI 1.02 to 5.8; P = 0.046), as well as for pregnancy-induced hypertension (OR 5.3, CI 1.1 to 25.2; P = 0.036), and caesarean delivery (OR 2.3, CI 1.4 to 3.7; P = 0.001) compared with pregnancies using autologous oocytes.
本研究的目的是评估与使用自体卵母细胞进行体外受精后的妊娠相比，卵母细胞捐赠后的妊娠发生子痫前期的风险是否更高。在产妇年龄和胎次方面进行一对一的倾向评分匹配，将通过卵母细胞捐赠实现的、妊娠22周后分娩的144例单胎妊娠与通过使用自体卵母细胞进行体外受精和卵胞浆内单精子注射实现的144例妊娠进行比较。所有妊娠均在新鲜胚胎移植后实现。比较每次妊娠的产科和新生儿结局。与使用自体卵母细胞的妊娠相比，卵母细胞捐赠后的单胎妊娠发生子痫前期的风险显著更高（比值比2.4，可信区间1.02至5.8；P = 0.046），妊娠高血压的风险也更高（比值比5.3，可信区间1.1至25.2；P = 0.036），剖宫产的风险也更高（比值比2.3，可信区间1.4至3.7；P = 0.001）。
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