Program in Cellular and Molecular Medicine, Boston Children's Hospital and Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA; Current address: Department of Cell Biology and Histology, Academic Medical Center, Amsterdam, 1105 AZ, The Netherlands.
Program in Cellular and Molecular Medicine, Boston Children's Hospital and Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA.
Trends Immunol. 2016 Dec;37(12):844-854. doi: 10.1016/j.it.2016.10.003. Epub 2016 Oct 25.
Unlike T cells that recognize digested peptides, B cells recognize their cognate antigen in its native form. The B cell receptor used in recognition can also be secreted to bind to antigens and initiate multiple effector functions such as phagocytosis, complement activation, or neutralization of receptors. While B cells can interact with soluble antigens, it is now clear that the presentation of membrane-bound antigen plays a crucial role in B cell activation, and in particular during affinity-maturation, the process during which high-affinity B cells are selected. In this review we discuss how native antigen is presented to B cells and its impact at several stages of B cell responses.
与识别消化肽的 T 细胞不同，B 细胞以其天然形式识别其同源抗原。用于识别的 B 细胞受体也可以分泌出来与抗原结合，并启动多种效应功能，如吞噬作用、补体激活或受体中和。虽然 B 细胞可以与可溶性抗原相互作用，但现在很清楚，膜结合抗原的呈递在 B 细胞激活中起着至关重要的作用，特别是在亲和力成熟过程中，高亲和力 B 细胞被选择。在这篇综述中，我们讨论了天然抗原如何呈递给 B 细胞及其在 B 细胞反应的几个阶段的影响。
