Pinho-Ribeiro Felipe A, Verri Waldiceu A, Chiu Isaac M
Department of Microbiology and Immunobiology, Division of Immunology, Harvard Medical School, Boston, MA 02115, USA; Departamento de Ciências Patológicas, Centro de Ciências Biológicas, Universidade Estadual de Londrina, Londrina, PR 10011, Brazil.
Departamento de Ciências Patológicas, Centro de Ciências Biológicas, Universidade Estadual de Londrina, Londrina, PR 10011, Brazil.
Trends Immunol. 2017 Jan;38(1):5-19. doi: 10.1016/j.it.2016.10.001. Epub 2016 Oct 25.
Nociceptor sensory neurons protect organisms from danger by eliciting pain and driving avoidance. Pain also accompanies many types of inflammation and injury. It is increasingly clear that active crosstalk occurs between nociceptor neurons and the immune system to regulate pain, host defense, and inflammatory diseases. Immune cells at peripheral nerve terminals and within the spinal cord release mediators that modulate mechanical and thermal sensitivity. In turn, nociceptor neurons release neuropeptides and neurotransmitters from nerve terminals that regulate vascular, innate, and adaptive immune cell responses. Therefore, the dialog between nociceptor neurons and the immune system is a fundamental aspect of inflammation, both acute and chronic. A better understanding of these interactions could produce approaches to treat chronic pain and inflammatory diseases.
伤害性感受器感觉神经元通过引发疼痛和促使机体产生回避行为来保护生物体免受危险。疼痛也伴随着多种类型的炎症和损伤。越来越明显的是，伤害性感受器神经元与免疫系统之间存在活跃的相互作用，以调节疼痛、宿主防御和炎症性疾病。外周神经末梢和脊髓内的免疫细胞释放调节机械和热敏感性的介质。反过来，伤害性感受器神经元从神经末梢释放神经肽和神经递质，调节血管、固有免疫和适应性免疫细胞反应。因此，伤害性感受器神经元与免疫系统之间的对话是急慢性炎症的一个基本方面。更好地理解这些相互作用可能会产生治疗慢性疼痛和炎症性疾病的方法。
