Hu Xianjing, Wei Mingyu, Zhang Heli, Wang Mingxuan, Zhang Siwei, Li Baohua
Department of Nursing, Peking University Third Hospital, Beijing, China.
Department of Cardiology and Institute of Vascular Medicine, Peking University Third Hospital, Beijing, China.
Neurol Sci. 2025 Aug 30. doi: 10.1007/s10072-025-08444-9.
To investigate the characteristics and influencing factors of pain symptoms in ALS patients, provide references for the formulation of pain coping measures in clinical practice.
The research design was a cross-sectional study.ALS patients were investigated using scales such as the Brief Pain Inventory (BPI). Binary logistic regression equation and multiple linear regression equation were used to analyze the influencing factors of whether occur pain and pain degree in ALS patients.
149 (74.1%) patients had pain symptoms, and 51 (25.4%) patients had pain as the first symptom. Patients with moderate to severe pain accounted for 60.4%. Fatigue, social support, self-efficacy, and poor sleep quality have been associated with whether occur pain in ALS patients. Personality traits, education, fatigue, social support, physical function, and self-efficacy were associated with pain levels in ALS patients.
Pain is an important indicator of functional decline, which can directly affect the rehabilitation outcome, reduce the quality of life of patients, and is crucial for predicting disease progression and optimizing end-of-life care, which should arouse the full attention of clinical medical personnel and scientific researchers. In the future, it is necessary to strengthen pain intervention in rehabilitation programs.
探讨肌萎缩侧索硬化症（ALS）患者疼痛症状的特点及影响因素，为临床实践中制定疼痛应对措施提供参考。
本研究设计为横断面研究。采用简明疼痛评估量表（BPI）等对ALS患者进行调查。运用二元逻辑回归方程和多元线性回归方程分析ALS患者疼痛发生与否及疼痛程度的影响因素。
149例（74.1%）患者有疼痛症状，51例（25.4%）患者以疼痛为首发症状。中重度疼痛患者占60.4%。疲劳、社会支持、自我效能感及睡眠质量差与ALS患者疼痛发生与否相关。人格特质、教育程度、疲劳、社会支持、身体功能及自我效能感与ALS患者疼痛程度相关。
疼痛是功能衰退的重要指标，可直接影响康复结局，降低患者生活质量，对预测疾病进展及优化临终关怀至关重要，应引起临床医务人员和科研人员的充分重视。未来有必要在康复项目中加强疼痛干预。
