Strachan Cameron R, Davies Julian
MetaMixis Biologics, Vancouver, BC V6T 1Z3, Canada.
Department of Microbiology and Immunology, University of British Columbia, Vancouver, BC V6T 1Z3, Canada.
Cold Spring Harb Perspect Med. 2017 Feb 1;7(2):a025171. doi: 10.1101/cshperspect.a025171.
The development and rapid dissemination of antibiotic-resistant bacterial pathogens has tarnished the dream of a world without infectious diseases. However, our understanding of these processes, paired with sequence information from terrestrial bacterial populations, indicates that there is no shortage of novel natural products that could be developed into new medicines. Regardless, their therapeutic success in the clinic will depend on the introduction of mandatory controls and use restrictions.
抗生素耐药性细菌病原体的出现和迅速传播,使无传染病世界的梦想破灭。然而,我们对这些过程的理解,再加上来自陆地细菌种群的序列信息,表明不乏可开发成新药的新型天然产物。无论如何,它们在临床上的治疗成功将取决于引入强制性管控措施和使用限制。