抗菌活性增强剂：迈向抗菌剂的智能递送
Antimicrobial Activity Enhancers: Towards Smart Delivery of Antimicrobial Agents.
作者信息
Skwarczynski Mariusz, Bashiri Sahra, Yuan Ye, Ziora Zyta M, Nabil Osama, Masuda Keita, Khongkow Mattaka, Rimsueb Natchanon, Cabral Horacio, Ruktanonchai Uracha, Blaskovich Mark A T, Toth Istvan
机构信息
School of Chemistry and Molecular Bioscience, The University of Queensland, Brisbane, QLD 4072, Australia.
Centre for Superbug Solutions, Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD 4072, Australia.
出版信息
Antibiotics (Basel). 2022 Mar 18;11(3):412. doi: 10.3390/antibiotics11030412.
The development of effective treatments against infectious diseases is an extensive and ongoing process due to the rapid adaptation of bacteria to antibiotic-based therapies. However, appropriately designed activity enhancers, including antibiotic delivery systems, can increase the effectiveness of current antibiotics, overcoming antimicrobial resistance and decreasing the chance of contributing to further bacterial resistance. The activity/delivery enhancers improve drug absorption, allow targeted antibiotic delivery, improve their tissue and biofilm penetration and reduce side effects. This review provides insights into various antibiotic activity enhancers, including polymer, lipid, and silver-based systems, designed to reduce the adverse effects of antibiotics and improve formulation stability and efficacy against multidrug-resistant bacteria.
由于细菌能迅速适应基于抗生素的治疗方法，因此开发有效的传染病治疗方法是一个广泛且持续的过程。然而，经过适当设计的活性增强剂，包括抗生素递送系统，可以提高现有抗生素的有效性，克服抗菌耐药性，并降低导致细菌产生进一步耐药性的可能性。这些活性/递送增强剂可改善药物吸收，实现靶向抗生素递送，增强其对组织和生物膜的穿透力，并减少副作用。本文综述了各种抗生素活性增强剂，包括聚合物、脂质和银基系统，这些系统旨在减少抗生素的不良反应，提高制剂稳定性以及对多重耐药菌的疗效。
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