血小板衍生生长因子A链转录本的可变剪接在正常细胞和肿瘤细胞中均会发生，并且在哺乳动物物种中保守存在。
Alternative splicing of the platelet-derived growth factor A-chain transcript occurs in normal as well as tumor cells and is conserved among mammalian species.
作者信息
Matoskova B, Rorsman F, Svensson V, Betsholtz C
机构信息
Department of Pathology, University Hospital, Uppsala, Sweden.
出版信息
Mol Cell Biol. 1989 Jul;9(7):3148-50. doi: 10.1128/mcb.9.7.3148-3150.1989.
Abstract
Using a polymerase chain reaction approach, we have analyzed the alternative usage of the platelet-derived growth factor A-chain exon 6 in mRNA from various cell types. The results show that this sequence is utilized in a small fraction of the mRNA molecules in normal as well as transformed cells and that this phenomenon is conserved among mammalian species.
摘要
我们采用聚合酶链反应方法，分析了来自各种细胞类型的mRNA中血小板衍生生长因子A链外显子6的可变使用情况。结果表明，在正常细胞和转化细胞中，只有一小部分mRNA分子利用了该序列，并且这种现象在哺乳动物物种中是保守的。
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