Chtaou Naima, Rachdi Lamyae, Midaoui Aouatef El, Souirti Zouhair, Wahlgren Nils, Belahsen Mohammed Faouzi
Neurology Department, Hassan II University Hospital, Fez, Morocco.
Neurology Department, Hassan II University Hospital, Fez, Morocco; Laboratory of Epidemiology and Public Health, Faculty of Medicine and Pharmacy, Sidi Mohammed BenAbdellah university Fez, Morocco.
Pan Afr Med J. 2016 Jul 8;24:207. doi: 10.11604/pamj.2016.24.207.8815. eCollection 2016.
The majority of strokes are due to blockage of an artery in the brain by a blood clot. Prompt treatment with thrombolytic drugs can restore blood flow before major brain damage has occurred. We report the case series of all patients who were treated with rt-PA at Stroke Unit of HASSAN II University hospital between 2010 and 2013. There were 52 patients treated with intravenous rtPA during the study period. The mean age was 63 years with the no gender predominance (sex ratio 1.02). Hypertension was the most common vascular risk factor (31%) and 17% of patients suffered from atrial fibrillation. 17 of 52 patients (32.7%) were treated within a 3 hours window of stroke onset and 35 of 52 (67.3%) patients were treated within 3-4.5 h. Twenty five patients (48%) had significant early improvements within 24 hours and twenty one (40.3%) patients had good outcomes at 3 months and fifteen patients (29%) died within the same period.
大多数中风是由于血凝块阻塞大脑中的动脉所致。在严重脑损伤发生之前，及时使用溶栓药物治疗可恢复血流。我们报告了2010年至2013年期间在哈桑二世大学医院卒中单元接受rt-PA治疗的所有患者的病例系列。研究期间有52例患者接受了静脉rtPA治疗。平均年龄为63岁，无性别优势（性别比为1.02）。高血压是最常见的血管危险因素（31%），17%的患者患有心房颤动。52例患者中有17例（32.7%）在中风发作3小时内接受治疗，52例中有35例（67.3%）患者在3至4.5小时内接受治疗。25例患者（48%）在24小时内有显著早期改善，21例（40.3%）患者在3个月时有良好预后，15例患者（29%）在同一时期死亡。
