含氯喹的HPMA共聚物作为CXCR4/SDF-1趋化因子轴介导的癌细胞迁移的聚合物抑制剂
Chloroquine-Containing HPMA Copolymers as Polymeric Inhibitors of Cancer Cell Migration Mediated by the CXCR4/SDF-1 Chemokine Axis.
作者信息
Yu Fei, Xie Ying, Wang Yan, Peng Zheng-Hong, Li Jing, Oupický David
机构信息
Center for Drug Delivery and Nanomedicine, Department of Pharmaceutical Sciences, University of Nebraska Medical Center, Omaha, Nebraska 68198, United States.
出版信息
ACS Macro Lett. 2016 Mar 15;5(3):342-345. doi: 10.1021/acsmacrolett.5b00857. Epub 2016 Feb 17.
Abstract
Chloroquine-containing HPMA copolymers (pCQs) were synthesized for the first time by copolymerization of methacryloylated hydroxychloroquine and HPMA. The copolymers showed lower cytotoxicity when compared with hydroxychloroquine. Treatment of cancer cells with pCQ resulted in decreased surface expression of chemokine receptor CXCR4. The pCQ copolymers showed effective inhibition of CXCR4/SDF1-mediated cancer cell migration that was fully comparable with a commercial small-molecule CXCR4 antagonist AMD3100. The reported pCQ represent unique and simple polymeric drugs with potential use as part of a combination antimetastatic therapies.
摘要
含氯喹的HPMA共聚物（pCQs）首次通过甲基丙烯酰化羟氯喹与HPMA的共聚反应合成。与羟氯喹相比，这些共聚物表现出较低的细胞毒性。用pCQ处理癌细胞导致趋化因子受体CXCR4的表面表达降低。pCQ共聚物显示出对CXCR4/SDF1介导的癌细胞迁移的有效抑制，这与市售小分子CXCR4拮抗剂AMD3100完全相当。所报道的pCQ代表了独特且简单的聚合物药物，具有作为联合抗转移疗法一部分的潜在用途。
相似文献
1
Chloroquine-Containing HPMA Copolymers as Polymeric Inhibitors of Cancer Cell Migration Mediated by the CXCR4/SDF-1 Chemokine Axis.含氯喹的HPMA共聚物作为CXCR4/SDF-1趋化因子轴介导的癌细胞迁移的聚合物抑制剂
ACS Macro Lett. 2016 Mar 15;5(3):342-345. doi: 10.1021/acsmacrolett.5b00857. Epub 2016 Feb 17.
2
Polymeric chloroquine as an inhibitor of cancer cell migration and experimental lung metastasis.聚合氯喹作为癌细胞迁移和实验性肺转移的抑制剂
J Control Release. 2016 Dec 28;244(Pt B):347-356. doi: 10.1016/j.jconrel.2016.07.040. Epub 2016 Jul 27.
3
The SDF-1/CXCR4 chemokine axis in uveal melanoma cell proliferation and migration.SDF-1/CXCR4趋化因子轴在葡萄膜黑色素瘤细胞增殖和迁移中的作用
Tumour Biol. 2016 Mar;37(3):4175-82. doi: 10.1007/s13277-015-4259-4. Epub 2015 Oct 22.
4
IL-24 inhibits lung cancer cell migration and invasion by disrupting the SDF-1/CXCR4 signaling axis.白细胞介素-24通过破坏基质细胞衍生因子-1/趋化因子受体4信号轴来抑制肺癌细胞的迁移和侵袭。
PLoS One. 2015 Mar 16;10(3):e0122439. doi: 10.1371/journal.pone.0122439. eCollection 2015.
5
Polymeric Chloroquine as an Effective Antimigration Agent in the Treatment of Pancreatic Cancer.聚合物氯喹作为胰腺癌治疗中的有效抗迁移剂。
Mol Pharm. 2022 Dec 5;19(12):4631-4643. doi: 10.1021/acs.molpharmaceut.2c00596. Epub 2022 Nov 8.
6
[Effect of chemokine stromal cell derived factor-1 and its receptor CXCR4 on the peritoneal carcinometastasis of gastric cancer].趋化因子基质细胞衍生因子-1及其受体CXCR4对胃癌腹膜转移的影响
Zhonghua Yi Xue Za Zhi. 2008 Jan 15;88(3):202-5.
7
Inhibition of tumor growth and histopathological changes following treatment with a chemokine receptor CXCR4 antagonist in a prostate cancer xenograft model.趋化因子受体CXCR4拮抗剂治疗前列腺癌异种移植模型后的肿瘤生长抑制及组织病理学变化
Oncol Lett. 2013 Oct;6(4):933-938. doi: 10.3892/ol.2013.1515. Epub 2013 Aug 6.
8
Pharmacokinetics and efficacy of orally administered polymeric chloroquine as macromolecular drug in the treatment of inflammatory bowel disease.口服聚合物氯喹作为大分子药物在治疗炎症性肠病中的药代动力学和疗效。
Acta Biomater. 2018 Dec;82:158-170. doi: 10.1016/j.actbio.2018.10.027. Epub 2018 Oct 17.
9
CXCR4 antagonist delivery on decellularized skin scaffold facilitates impaired wound healing in diabetic mice by increasing expression of SDF-1 and enhancing migration of CXCR4-positive cells.在脱细胞皮肤支架上递送CXCR4拮抗剂，通过增加SDF-1的表达和增强CXCR4阳性细胞的迁移，促进糖尿病小鼠受损伤口的愈合。
Wound Repair Regen. 2017 Aug;25(4):652-664. doi: 10.1111/wrr.12552. Epub 2017 Aug 7.
10
Granulocyte colony-stimulating factor inhibits CXCR4/SDF-1α signaling and overcomes stromal-mediated drug resistance in the HL-60 cell line.粒细胞集落刺激因子抑制HL-60细胞系中的CXCR4/SDF-1α信号传导并克服基质介导的耐药性。
Exp Ther Med. 2016 Jul;12(1):396-404. doi: 10.3892/etm.2016.3268. Epub 2016 Apr 20.
引用本文的文献
1
Cell surface patching via CXCR4-targeted nanothreads for cancer metastasis inhibition.通过靶向 CXCR4 的纳米线进行细胞表面修补以抑制癌症转移。
Nat Commun. 2024 Mar 29;15(1):2763. doi: 10.1038/s41467-024-47111-z.
2
Biologic Functions of Hydroxychloroquine in Disease: From COVID-19 to Cancer.羟氯喹在疾病中的生物学功能：从新冠病毒疾病到癌症
Pharmaceutics. 2022 Nov 22;14(12):2551. doi: 10.3390/pharmaceutics14122551.
3
A Review of Modifications of Quinoline Antimalarials: Mefloquine and (hydroxy)Chloroquine.喹啉类抗疟药的修饰综述：甲氟喹和（羟基）氯喹。
Molecules. 2022 Feb 2;27(3):1003. doi: 10.3390/molecules27031003.
4
Quinine copolymer reporters promote efficient intracellular DNA delivery and illuminate a protein-induced unpackaging mechanism.奎宁共聚物报告分子促进高效的细胞内 DNA 递送，并阐明了一种蛋白诱导的解包机制。
Proc Natl Acad Sci U S A. 2020 Dec 29;117(52):32919-32928. doi: 10.1073/pnas.2016860117. Epub 2020 Dec 14.
5
Expression levels of CXCR4 and CXCL12 in patients with rheumatoid arthritis and its correlation with disease activity.类风湿关节炎患者CXCR4和CXCL12的表达水平及其与疾病活动度的相关性。
Exp Ther Med. 2020 Sep;20(3):1925-1934. doi: 10.3892/etm.2020.8950. Epub 2020 Jun 26.
6
Association of CXCL13 and Immune Cell Infiltration Signature in Clear Cell Renal Cell Carcinoma.CXCL13 与透明细胞肾细胞癌免疫细胞浸润特征的关联。
Int J Med Sci. 2020 Jun 27;17(11):1610-1624. doi: 10.7150/ijms.46874. eCollection 2020.
7
Determinants of preferential renal accumulation of synthetic polymers in acute kidney injury.急性肾损伤中合成聚合物优先在肾脏蓄积的决定因素。
Int J Pharm. 2019 Sep 10;568:118555. doi: 10.1016/j.ijpharm.2019.118555. Epub 2019 Jul 22.
8
Promise of chemokine network-targeted nanoparticles in combination nucleic acid therapies of metastatic cancer.化学趋化因子网络靶向纳米粒联合核酸治疗转移性癌症的前景。
Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2019 Mar;11(2):e1528. doi: 10.1002/wnan.1528. Epub 2018 Apr 26.
9
Synthesis and Evaluation of Chloroquine-Containing DMAEMA Copolymers as Efficient Anti-miRNA Delivery Vectors with Improved Endosomal Escape and Antimigratory Activity in Cancer Cells.含氯喹的 DMAEMA 共聚物的合成与评价作为有效的抗 miRNA 递送载体，具有改善的内涵体逃逸和抗迁移活性在癌细胞中。
Macromol Biosci. 2018 Jan;18(1). doi: 10.1002/mabi.201700194. Epub 2017 Aug 4.
10
Chloroquine-Modified Hydroxyethyl Starch as a Polymeric Drug for Cancer Therapy.氯喹改性羟乙基淀粉作为一种用于癌症治疗的聚合物药物。
Biomacromolecules. 2017 Aug 14;18(8):2247-2257. doi: 10.1021/acs.biomac.7b00023. Epub 2017 Jul 14.
本文引用的文献
1
Polymeric drugs: Advances in the development of pharmacologically active polymers.聚合物药物：具有药理活性聚合物开发的进展
J Control Release. 2015 Dec 10;219:369-382. doi: 10.1016/j.jconrel.2015.09.043. Epub 2015 Sep 26.
2
Molecular Pathways: Targeting the CXCR4-CXCL12 Axis--Untapped Potential in the Tumor Microenvironment.分子途径：靶向 CXCR4-CXCL12 轴——肿瘤微环境中的未开发潜力。
Clin Cancer Res. 2015 Oct 1;21(19):4278-85. doi: 10.1158/1078-0432.CCR-14-0914. Epub 2015 Jul 21.
3
Polymer antidotes for toxin sequestration.聚合物解毒剂用于毒素隔离。
Adv Drug Deliv Rev. 2015 Aug 1;90:81-100. doi: 10.1016/j.addr.2015.05.011. Epub 2015 May 27.
4
A synthetic fibrin cross-linking polymer for modulating clot properties and inducing hemostasis.一种用于调节血凝块特性和诱导止血的合成纤维蛋白交联聚合物。
Sci Transl Med. 2015 Mar 4;7(277):277ra29. doi: 10.1126/scitranslmed.3010383.
5
CXCR4 over-expression and survival in cancer: a system review and meta-analysis.CXCR4过表达与癌症患者生存情况：一项系统评价与Meta分析
Oncotarget. 2015 Mar 10;6(7):5022-40. doi: 10.18632/oncotarget.3217.
6
HPMA Copolymer CXCR4 Antagonist Conjugates Substantially Inhibited the Migration of Prostate Cancer Cells.HPMA共聚物CXCR4拮抗剂缀合物显著抑制前列腺癌细胞的迁移。
ACS Macro Lett. 2014 Dec 16;3(12):1240-1243. doi: 10.1021/mz5006537. Epub 2014 Nov 17.
7
Development of functional poly(amido amine) CXCR4 antagonists with the ability to mobilize leukocytes and deliver nucleic acids.具有动员白细胞和递送核酸能力的功能性聚（酰胺-胺）CXCR4 拮抗剂的开发。
Adv Healthc Mater. 2015 Apr 2;4(5):729-38. doi: 10.1002/adhm.201400608. Epub 2014 Dec 9.
8
An improved D-α-tocopherol-based nanocarrier for targeted delivery of doxorubicin with reversal of multidrug resistance.一种改进的基于D-α-生育酚的纳米载体，用于阿霉素的靶向递送并逆转多药耐药性。
J Control Release. 2014 Dec 28;196:272-86. doi: 10.1016/j.jconrel.2014.10.016. Epub 2014 Oct 24.
9
The chemotherapeutic potential of PEG-b-PLGA copolymer micelles that combine chloroquine as autophagy inhibitor and docetaxel as an anti-cancer drug.聚乙二醇-聚乳酸-羟基乙酸共聚物胶束的化学治疗潜力，该胶束结合了氯喹作为自噬抑制剂和多西他赛作为抗癌药物。
Biomaterials. 2014 Nov;35(33):9144-54. doi: 10.1016/j.biomaterials.2014.07.028. Epub 2014 Aug 7.
10
Chloroquine targets pancreatic cancer stem cells via inhibition of CXCR4 and hedgehog signaling.氯喹通过抑制CXCR4和刺猬信号通路靶向胰腺癌干细胞。
Mol Cancer Ther. 2014 Jul;13(7):1758-71. doi: 10.1158/1535-7163.MCT-13-0948. Epub 2014 Apr 30.
Zotero 插件