Jabbari B, Scherokman B, Gunderson C H, Rosenberg M L, Miller J
Neurology Services of Walter Reed Army Medical Center, Washington, D.C. 20307-5001.
Mov Disord. 1989;4(3):202-12. doi: 10.1002/mds.870040302.
The clinical efficacy of the trihexyphenidyl was investigated in 100 patients with movement disorders. The study group consisted of 54 women and 46 men. Their ages ranged from 18 to 70 years, and their duration of illness varied from a few months to 36 years. Each patient had a videotape of the movements and a neurological examination, before administration of the drug, at the time of maximum or effective dosage, and one week after withdrawal from trihexyphenidyl. The drug was administered at an initial total daily dose of 2 mg and gradually increased to a total daily dose of 60 mg over a period of 4-6 weeks. Improvements were rated both clinically and from the videotapes. Three groups of movement disorders demonstrated a significant response to trihexyphenidyl: (1) dystonia 37%; tonic torticollis demonstrated a significantly better response than the clonic variant (80% vs. 22%). (2) rhythmic-oscillatory movements of brainstem-cerebellar origin (palatal myoclonus, pendular nystagmus, facial myokymia) 90%; (3) cerebellar tremor 75%. Among 32 responders, 17 (56%) continued taking trihexyphenidyl beyond 24 months. Side effects consisted of dryness of the mouth, jitteriness, stomatitis, blurred vision, and forgetfulness.
对100例运动障碍患者研究了苯海索的临床疗效。研究组包括54名女性和46名男性。他们的年龄在18岁至70岁之间，病程从几个月到36年不等。每位患者在用药前、最大或有效剂量时以及停用苯海索一周后均有运动录像带并接受神经学检查。药物初始每日总剂量为2毫克，在4至6周内逐渐增加至每日总剂量60毫克。从临床和录像带两方面对改善情况进行评分。三组运动障碍对苯海索有显著反应：（1）肌张力障碍37%；强直性斜颈的反应明显优于阵挛性变体（80%对22%）。（2） 脑干 - 小脑起源的节律性振荡运动（腭肌阵挛、摆动性眼球震颤、面部肌束震颤）90%；（3） 小脑性震颤75%。在32名有反应者中，17名（56%）持续服用苯海索超过24个月。副作用包括口干、神经过敏、口腔炎、视力模糊和健忘。
