Shoji Takuhei, Kuroda Hiroto, Suzuki Masayuki, Ibuki Hisashi, Araie Makoto, Yoneya Shin
Department of Ophthalmology, Saitama Medical University, 38 Morohongo Moroyama-machi, Iruma, Saitama, 350-0495, Japan.
Advanced Laser Medical Center, Department of Ophthalmology, Saitama Medical University, Iruma, Saitama, Japan.
Graefes Arch Clin Exp Ophthalmol. 2017 Jan;255(1):197-205. doi: 10.1007/s00417-016-3524-6. Epub 2016 Oct 28.
Morphological features of the lamina cribrosa (LC) and optic disc may be important in the pathogenesis of glaucoma and myopic neuropathy. We therefore performed a cross-sectional study of patients with glaucoma and myopic neuropathy to evaluate vertical asymmetry of LC tilt angles (LCTAs) from Bruch's membrane opening (BMO).
Forty-six control eyes and 35 primary open-angle glaucoma (POAG) eyes were included. A raster scanning protocol with 300 single B-scans (without averaging) were obtained using optical coherence tomography with a wide-bandwidth, femtosecond mode-locked (ML) laser. Superior temporal to inferior nasal (ST) direction and inferior temporal to superior nasal (IT) direction (±45° rotation with a horizontal line) lines were drawn, and the angle between the inner edge of the BMO plane and the best fitting line for the anterior LC plane was measured as the LCTA. The generalized estimating equation was used to analyze the eye-derived data.
Although no significant differences in either ST-LTCAs or IT-LTCAs were observed between the glaucoma group and non-glaucoma group, the IT-LCTAs were found to be significantly greater than the ST-LCTA in both the glaucoma and non-glaucoma groups (P < 0.001). After adjustment for other potential confounding factors by multivariate analysis, greater refractive errors were significantly correlated with IT-LCTAs.
Vertical asymmetry of the LC tilting from the BMO plane exists in both normal and POAG eyes, and correlates with the degree of myopia.
筛板（LC）和视盘的形态学特征可能在青光眼和近视性神经病变的发病机制中起重要作用。因此，我们对青光眼和近视性神经病变患者进行了一项横断面研究，以评估从布鲁赫膜开口（BMO）处测量的LC倾斜角（LCTA）的垂直不对称性。
纳入46只对照眼和35只原发性开角型青光眼（POAG）眼。使用宽带飞秒锁模（ML）激光光学相干断层扫描技术，采用300次单B扫描（不平均）的光栅扫描方案。绘制颞上至鼻下（ST）方向和颞下至鼻上（IT）方向（与水平线±45°旋转）的线，并将BMO平面的内边缘与前LC平面的最佳拟合线之间的角度测量为LCTA。使用广义估计方程分析眼源性数据。
虽然青光眼组和非青光眼组在ST-LCTA或IT-LCTA方面均未观察到显著差异，但在青光眼组和非青光眼组中，IT-LCTA均显著大于ST-LCTA（P < 0.001）。通过多变量分析对其他潜在混杂因素进行校正后，更大的屈光不正与IT-LCTA显著相关。
正常眼和POAG眼中均存在从BMO平面测量的LC倾斜的垂直不对称性，且与近视程度相关。
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