Devers Eye Institute, Optic Nerve Head Research Laboratory, Legacy Research Institute, Portland, Oregon, USA; Department of Ophthalmology, Medical College, the Catholic University of Korea, Seoul, Korea.
Devers Eye Institute, Optic Nerve Head Research Laboratory, Legacy Research Institute, Portland, Oregon, USA.
Am J Ophthalmol. 2019 Dec;208:185-205. doi: 10.1016/j.ajo.2019.05.009. Epub 2019 May 13.
To assess anterior scleral canal opening (ASCO) offset relative to Bruch's membrane opening (BMO) (ASCO/BMO offset) so as to determine neural canal direction, obliqueness, and minimum cross-sectional area (NCMCA) in 362 healthy eyes.
Cross-sectional study.
After optical coherence tomography optic nerve head and retinal nerve fiber layer thickness (RNFLT) imaging, BMO and ASCO were manually segmented. Planes, centroids, size, and shape were calculated. Neural canal direction was defined by projecting the neural canal axis vector (connecting BMO and ASCO centroids) onto the BMO plane. Neural canal obliqueness was defined by the angle between the neural canal axis and the BMO plane perpendicular vector. NCMCA was defined by projecting BMO and ASCO points onto a neural canal axis perpendicular plane and measuring the area of overlap. The angular distance between superior and inferior peak RNFLT was measured, and correlations between RFNLT, BMO, ASCO, ASCO/BMO offset, and NCMCA were assessed.
Mean (SD) NCMCA was significantly smaller than either the BMO or ASCO area (1.33 (0.42), 1.82 (0.38), 2.22 (0.43) mm, respectively), and most closely correlated to RNFLT (P < .001, R = 0.158). Neural canal direction was most commonly superior-nasal (55%). Mean neural canal obliqueness was 39.4° (17.3°). The angular distance between superior and inferior peak RNFLT correlated to neural canal direction (P ≤ .008, R = 0.093).
ASCO/BMO offset underlies neural canal direction, obliqueness, and NCMCA. RNFLT is more strongly correlated to NCMCA than to BMO or ASCO, and its peripapillary distribution is influenced by neural canal direction.
评估巩膜前管开口（ASCO）相对于Bruch 膜开口（BMO）的偏移（ASCO/BMO 偏移），以确定 362 只健康眼中神经管的方向、倾斜度和最小横截面积（NCMCA）。
横断面研究。
在光学相干断层扫描视神经头和视网膜神经纤维层厚度（RNFLT）成像后，手动分割 BMO 和 ASCO。计算平面、质心、大小和形状。通过将神经管轴向量（连接 BMO 和 ASCO 质心）投影到 BMO 平面上，定义神经管方向。通过将神经管轴与 BMO 平面垂直向量之间的夹角定义神经管倾斜度。通过将 BMO 和 ASCO 点投影到神经管轴垂直平面上并测量重叠面积，定义 NCMCA。测量上下峰 RNFLT 的角距，并评估 RFNLT、BMO、ASCO、ASCO/BMO 偏移和 NCMCA 之间的相关性。
NCMCA 的平均值（标准差）显著小于 BMO 或 ASCO 面积（分别为 1.33（0.42）、1.82（0.38）、2.22（0.43）mm），与 RNFLT 相关性最强（P<0.001，R=0.158）。神经管方向最常见于上鼻侧（55%）。平均神经管倾斜度为 39.4°（17.3°）。上下峰 RNFLT 的角距与神经管方向相关（P≤0.008，R=0.093）。
ASCO/BMO 偏移是神经管方向、倾斜度和 NCMCA 的基础。RNFLT 与 NCMCA 的相关性强于与 BMO 或 ASCO 的相关性，其视盘周围分布受神经管方向的影响。
