Goto Yasuyuki, Syam Ari Fahrial, Darnindro Nikko, Puspita Hapsari Florentina Carolin
Department of Gastroenterology, Nagoya Kyoritsu Hospital, Nagoya, Japan E-mail :
Asian Pac J Cancer Prev. 2016;17(9):4469-4475.
Indonesia is a developing country, in most of which the infection rates of Helicobacter pylori (H. pylori) have been reported to be high. However, the prevalence of H. pylori infection in Indonesia has been unexpectedly reported to be low. The purpose of our study was to con rm whether the prevalence of H. pylori infection is low among healthy inhabitants in Northern Jakarta by 13C-urea breath test (UBT), and to examine the association of their lifestyle/environmental factors with H. pylori infection and to identify potential routes of transmission. We recruited a total of 196 subjects from a low-income community in Northern Jakarta, Indonesia. Of them, 193 subjects who completed a questionnaire about their lifestyle/environment and had UBT were included in this study. Odds ratios (ORs) adjusted for sex and age with 95% con dence intervals (CIs) were calculated using logistic regression model. The overall H. pylori infection rate was 15.0%. There was difference in H. pylori infection rates among Buginese (40.0%), Betawi (9.1%), Sundanese (3.7%), and Batak (9.1%). After multivariate analysis, the ORs of intake of soybean milk, cucumber more than one time a week, infrequent hand washing before meals, and alcohol consumption were 0.10 (95%CI: 0.01-0.97), 6.61 (95%CI: 1.87-23.3), 4.10 (95%CI: 1.15-14.6), and 61.9 for former drinkers (95%CI: 1.67-2300.8), respectively. Buginese (OR=7.84; 95%CI: 1.82- 33.8) and Batak ethnic groups (OR=20.1; 95%CI: 1.90-213.2) were infected more frequently, compared with Javanese. The H. pylori infection rate in this study was low, as reported previously. After we scrutinized the factors, Buginese and Batak ethnic groups eat food using ngers more frequently than Javanese, Betawi, and Sundanese. In addition, infrequent hand wash practice before meal increased the risk. Our study indicated that person-person transmission was possible in this low prevalence area. The low infection rates of H. pylori among those of Javanese, Betawi, and Sundanese ethnicity could be partly due to sanitary practice.
印度尼西亚是一个发展中国家，据报道该国大部分地区幽门螺杆菌（H. pylori）感染率较高。然而，出人意料的是，有报道称印度尼西亚幽门螺杆菌感染率较低。我们研究的目的是通过13C尿素呼气试验（UBT）来确认雅加达北部健康居民中幽门螺杆菌感染率是否较低，并研究他们的生活方式/环境因素与幽门螺杆菌感染之间的关联，以及确定潜在的传播途径。我们从印度尼西亚雅加达北部的一个低收入社区共招募了196名受试者。其中，193名完成了关于其生活方式/环境的问卷调查并进行了UBT的受试者被纳入本研究。使用逻辑回归模型计算经性别和年龄调整的比值比（OR）及95%置信区间（CI）。幽门螺杆菌总体感染率为15.0%。布吉人（40.0%）、巽他人（9.1%）、爪哇人（3.7%）和巴塔克人（9.1%）的幽门螺杆菌感染率存在差异。多因素分析后，每周饮用豆浆、黄瓜超过一次、饭前不常洗手以及饮酒的OR分别为0.10（95%CI：0.01 - 0.97）、6.61（95%CI：1.87 - 23.3）、4.10（95%CI：1.15 - 14.6）以及既往饮酒者为61.9（95%CI：1.67 - 2300.8）。与爪哇人相比，布吉人（OR = 7.84；95%CI：1.82 - 33.8）和巴塔克族（OR = 20.1；95%CI：1.90 - 213.2）感染更为频繁。如先前报道的那样，本研究中的幽门螺杆菌感染率较低。在我们仔细研究这些因素后发现，布吉人和巴塔克族比爪哇人、巽他人和巽他人更频繁地用手指抓食物。此外，饭前不常洗手会增加感染风险。我们的研究表明，在这个低流行地区可能存在人传人现象。爪哇人、巽他人和巽他人族中幽门螺杆菌感染率较低可能部分归因于卫生习惯。
