a Biotechnology Research Center and Students' Research Committee, Faculty of Pharmacy , Tabriz University of Medical Sciences , Tabriz , Iran.
b Department of Pharmaceutics, Faculty of Pharmacy , Zanjan University of Medical Sciences , Zanjan , Iran.
Artif Cells Nanomed Biotechnol. 2017 Nov;45(7):1379-1387. doi: 10.1080/21691401.2016.1241794. Epub 2016 Oct 31.
The use of lipidic nanoparticles can overcome the limitations of skin penetration of hydrophilic charged materials. Oleic acid as an ion pairing agent was used to enhance the encapsulation of positively charged arginine into lipophilic nanostructured lipid carrier (NLC). Histological study on the male hamsters was performed to assess the efficiency of drug delivery on hair growth. The accumulation of NLCs in the hair follicles was verified and in vivo studies showed more new hair follicle growth by utilizing arginine-loaded NLCs than arginine aqueous solution. It was concluded that employing ion pairing agent could enhance drug encapsulation into NLCs structure.
脂质纳米粒的应用可以克服亲水性带电荷材料的皮肤渗透限制。油酸作为离子对试剂，用于增强正电荷精氨酸包封到亲脂性纳米结构化脂质载体（NLC）中。对雄性仓鼠进行组织学研究，以评估对毛发生长的药物递送效率。验证了 NLC 在毛囊中的积累，体内研究表明，与精氨酸水溶液相比，利用负载精氨酸的 NLC 可以促进更多的新毛囊生长。结论是，使用离子对试剂可以增强药物包封到 NLC 结构中。
