终末补体复合物在多发性硬化症中的免疫细胞化学定位

Immunocytochemical localization of the terminal complement complex in multiple sclerosis.

作者信息

Compston D A, Morgan B P, Campbell A K, Wilkins P, Cole G, Thomas N D, Jasani B

机构信息

Department of Neurology, University of Wales College of Medicine, Heath Park, Cardiff.

出版信息

Neuropathol Appl Neurobiol. 1989 Jul-Aug;15(4):307-16. doi: 10.1111/j.1365-2990.1989.tb01231.x.

DOI:10.1111/j.1365-2990.1989.tb01231.x

PMID:2779734

Abstract

Granular deposits of C9 and the terminal complement complex, measuring 0.3-1.2 microns, have been demonstrated immunocytochemically in association with capillary endothelial cells, predominantly within plaques and adjacent white matter, in tissue obtained at autopsy from 5/7 patients with multiple sclerosis (MS) and one individual with subacute sclerosing panencephalitis but not from 7/7 controls. This finding suggests that the evolution of focal tissue damage in MS may involve complement activation associated with passage of humoral and cellular mediators of the immune system through the blood-brain barrier.

摘要

通过免疫细胞化学方法已证实，在7例多发性硬化症（MS）患者中的5例以及1例亚急性硬化性全脑炎患者尸检获得的组织中，与毛细血管内皮细胞相关的、大小为0.3 - 1.2微米的C9颗粒沉积物和终末补体复合物主要存在于斑块及相邻白质中，而7例对照者中未发现。这一发现表明，MS中局灶性组织损伤的演变可能涉及补体激活，这与免疫系统的体液和细胞介质通过血脑屏障有关。