碳离子放疗后头颈癌患者放射性腮腺萎缩
Radiation-induced Parotid Gland Atrophy in Patients with Head and Neck Cancer After Carbon-ion Radiotherapy.
作者信息
Morikawa Takamichi, Koto Masashi, Hasegawa Azusa, Takagi Ryo, Fujikawa Akira, Tsuji Hiroshi, Shibahara Takahiko, Kamada Tadashi
机构信息
National Institute of Radiological Science Hospital, National Institutes for Quantum and Radiological Sciences and Technology, Chiba, Japan.
Department of Oral and Maxillofacial Surgery, Tokyo Dental College, Chiba, Japan.
出版信息
Anticancer Res. 2016 Oct;36(10):5403-5407. doi: 10.21873/anticanres.11116.
BACKGROUND/AIM: This study aimed to clarify the relationship between dosimetric factors and parotid gland (PG) atrophy after carbon ion radiotherapy (C-ion RT).
PATIENTS AND METHODS
Fifty-four patients with head and neck tumours were enrolled and 93 irradiated PGs were analyzed. Thirty and 24 patients were treated with total doses [relative biological effectiveness (RBE)] of 57.6 Gy and 64.0 Gy, respectively, in 16 fractions. PG volumes were measured using computed tomographic images obtained before C-ion RT and every 3-6 months thereafter.
RESULTS
The median follow-up period was 46.4 months (range=24.0-123.0 months). Univariate analysis showed that PG volumes receiving more than 5, 10, 15, and 20 Gy RBE (V5, V10, V15 and V20, respectively), mean dose, and maximum dose were significantly associated with PG atrophy. Multivariate analysis indicated that only V5 was significantly associated with atrophy.
CONCLUSION
Increasing V5 was a significant risk factor for PG atrophy after C-ion RT.
背景/目的：本研究旨在阐明碳离子放疗（C离子放疗）后剂量学因素与腮腺（PG）萎缩之间的关系。
患者与方法
纳入54例头颈部肿瘤患者，对93个接受照射的腮腺进行分析。30例和24例患者分别接受了16次分割的总剂量[相对生物效应（RBE）]为57.6 Gy和64.0 Gy的治疗。使用C离子放疗前及之后每3 - 6个月获取的计算机断层扫描图像测量腮腺体积。
结果
中位随访期为46.4个月（范围 = 24.0 - 123.0个月）。单因素分析显示，接受超过5、10、15和20 Gy RBE的腮腺体积（分别为V5、V10、V15和V20）、平均剂量和最大剂量与腮腺萎缩显著相关。多因素分析表明，仅V5与萎缩显著相关。
结论
C离子放疗后，V5增加是腮腺萎缩的显著危险因素。
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