一种预测妇科恶性肿瘤转移性硬膜外脊髓压迫患者生存预后的评分工具。

A Scoring Instrument to Predict the Survival Prognoses of Patients with Metastatic Epidural Spinal Cord Compression from Gynecological Malignancies.

作者信息

Janssen Stefan, Bajrovic Amira, Schild Steven E, Rades Dirk

机构信息

Department of Radiation Oncology, University of Lübeck, Lübeck, Germany.

Medical Practice of Radiotherapy and Radiation Oncology, Hannover, Germany.

出版信息

Anticancer Res. 2016 Oct;36(10):5469-5472. doi: 10.21873/anticanres.11127.

DOI:10.21873/anticanres.11127

PMID:27798917

Abstract

AIM

To design a scoring instrument for rating overall survival (OS) of patients with metastatic epidural sinal cord compression (MESCC) from gynecological malignancies.

PATIENTS AND METHODS

In 22 patients treated with radiotherapy alone for MESCC from gynecological malignancies, ten factors were analyzed for effects on OS. Factors significantly associated with OS on multivariate analysis were included in a scoring instrument.

RESULTS

On multivariate analyses, no visceral metastases (p=0.004) and affection of 1-2 vertebrae (p=0.012) were significant. Scoring points for each factor were 0 or 1, depending on OS rates. After summing, scores of 0 (n=6), 1 (n=9) or 2 points (n=9) were obtained. OS rates were 0%, 78% and 100%, respectively, at 3 months and 0%, 33% and 86%, respectively, at 6 months (p<0.001).

CONCLUSION

An instrument was developed for estimating the lifespan of patients with MESCC from gynecological malignancies. This instrument can support physicians when picking an individual treatment.

摘要

目的

设计一种评分工具，用于评估妇科恶性肿瘤转移性硬膜外脊髓压迫（MESCC）患者的总生存期（OS）。

患者与方法

对22例仅接受放疗治疗的妇科恶性肿瘤MESCC患者，分析10个因素对OS的影响。多因素分析中与OS显著相关的因素被纳入评分工具。

结果

多因素分析显示，无内脏转移（p = 0.004）和1 - 2个椎体受累（p = 0.012）具有显著性。根据OS率，每个因素的评分点为0或1。求和后，分别得到0分（n = 6）、1分（n = 9）或2分（n = 9）。3个月时的OS率分别为0%、78%和100%，6个月时分别为0%、33%和86%（p < 0.001）。