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本文引用的文献

1
Clinical Practice Guideline for the Management of Candidiasis: 2016 Update by the Infectious Diseases Society of America.《念珠菌病管理临床实践指南：美国传染病学会2016年更新版》
Clin Infect Dis. 2016 Feb 15;62(4):e1-50. doi: 10.1093/cid/civ933. Epub 2015 Dec 16.
2
Potential Microbiological Effects of Higher Dosing of Echinocandins.棘白菌素类药物高剂量给药的潜在微生物学效应。
Clin Infect Dis. 2015 Dec 1;61 Suppl 6:S669-77. doi: 10.1093/cid/civ725.
3
Echinocandin Resistance in Candida.念珠菌中的棘白菌素耐药性
Clin Infect Dis. 2015 Dec 1;61 Suppl 6(Suppl 6):S612-7. doi: 10.1093/cid/civ791.
4
Echinocandin resistance: an emerging clinical problem?棘白菌素耐药性：一个新出现的临床问题？
Curr Opin Infect Dis. 2014 Dec;27(6):484-92. doi: 10.1097/QCO.0000000000000111.
5
Real-world experience with echinocandin MICs against Candida species in a multicenter study of hospitals that routinely perform susceptibility testing of bloodstream isolates.在一项对常规进行血流分离株药敏试验的医院进行的多中心研究中，棘白菌素对念珠菌属的最低抑菌浓度（MIC）的真实世界经验。
Antimicrob Agents Chemother. 2014;58(4):1897-906. doi: 10.1128/AAC.02163-13. Epub 2014 Jan 6.
6
Paradoxical growth of Candida albicans in the presence of caspofungin is associated with multiple cell wall rearrangements and decreased virulence.卡泊芬净存在时白色念珠菌的反常生长与多个细胞壁重排和毒力降低有关。
Antimicrob Agents Chemother. 2014;58(2):1071-83. doi: 10.1128/AAC.00946-13. Epub 2013 Dec 2.
7
The Eagle-like effect of echinocandins: what's in a name?棘白菌素类的鹰样效应：名称中有何玄机？
Expert Rev Anti Infect Ther. 2013 Nov;11(11):1179-91. doi: 10.1586/14787210.2013.841543. Epub 2013 Oct 18.
8
Interlaboratory variability of Caspofungin MICs for Candida spp. Using CLSI and EUCAST methods: should the clinical laboratory be testing this agent?使用CLSI和EUCAST方法检测念珠菌属对卡泊芬净的最低抑菌浓度（MIC）的实验室间变异性：临床实验室是否应该检测这种药物？
Antimicrob Agents Chemother. 2013 Dec;57(12):5836-42. doi: 10.1128/AAC.01519-13. Epub 2013 Sep 9.
9
Antifungal lock therapy.抗真菌锁治疗。
Antimicrob Agents Chemother. 2013 Jan;57(1):1-8. doi: 10.1128/AAC.masthead.57-1. Epub 2012 Oct 15.
10
EUCAST technical note on the EUCAST definitive document EDef 7.2: method for the determination of broth dilution minimum inhibitory concentrations of antifungal agents for yeasts EDef 7.2 (EUCAST-AFST).EUCAST 技术说明：EUCAST 确诊文件 EDef 7.2：抗真菌药物检测酵母菌肉汤稀释最低抑菌浓度的方法（EUCAST-AFST）。
Clin Microbiol Infect. 2012 Jul;18(7):E246-7. doi: 10.1111/j.1469-0691.2012.03880.x. Epub 2012 May 8.

使用欧洲抗菌药物敏感性试验委员会（EUCAST）程序测定米卡芬净、阿尼芬净和卡泊芬净对引起念珠菌血症的念珠菌属分离株的矛盾效应发生率。

Frequency of the Paradoxical Effect Measured Using the EUCAST Procedure with Micafungin, Anidulafungin, and Caspofungin against Candida Species Isolates Causing Candidemia.

作者信息

Marcos-Zambrano Laura Judith, Escribano Pilar, Sánchez-Carrillo Carlos, Bouza Emilio, Guinea Jesús

机构信息

Clinical Microbiology and Infectious Diseases, Hospital General Universitario Gregorio Marañón, Madrid, Spain.

Instituto de Investigación Sanitaria Gregorio Marañón, Madrid, Spain.

出版信息

Antimicrob Agents Chemother. 2016 Dec 27;61(1). doi: 10.1128/AAC.01584-16. Print 2017 Jan.

DOI:10.1128/AAC.01584-16
PMID:27799221
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5192150/
Abstract

We report data on the frequency of the paradoxical effect of echinocandins against Candida spp. (n = 602 incident isolates) using the EUCAST definitive document EDef 7.2 procedure. The paradoxical effect for one or more echinocandins was observed in 16% of the isolates. However, differences between species were found, and the paradoxical effect was more common in Candida tropicalis (P < 0.001). Caspofungin was the drug in which the paradoxical effect was most common, followed by anidulafungin and micafungin (P < 0.001).

摘要

我们使用欧洲抗菌药物敏感性试验委员会（EUCAST）的权威文件EDef 7.2程序，报告了棘白菌素对念珠菌属（n = 602株初发分离株）产生矛盾效应的频率数据。在16%的分离株中观察到一种或多种棘白菌素产生矛盾效应。然而，发现不同菌种之间存在差异，矛盾效应在热带念珠菌中更为常见（P < 0.001）。卡泊芬净是产生矛盾效应最常见的药物，其次是阿尼芬净和米卡芬净（P < 0.001）。