Dozaki T, Imai K, Mizukami S
Nihon Yakurigaku Zasshi. 1975 Jul;71(5):405-14.
Adrenaline-induced gastric ulceration was studied in rats. Adrenaline in high doses caused gastric ulcer, which was completely blocked by pretreatment with alpha-blockers (phenoxybenzamine, dibenamine), but not by pretreatment with propranolol or atropine, nor by vagotomy, hypophysectomy or adrenalectomy. After successive administration of adrenaline, once daily for 7 days, however, no gastric ulcer was observed. Recovery from the ulcerogenic action of adrenaline was seen after 4 weeks withdrawal. Pretreatment with a small dose of adrenaline inhibited the ulcerogenic action of a high dose of adrenaline. Pretreatment with reserpine, pyrogallol or iproniazid inhibited the action of adrenaline. It is concluded that adrenaline has a biphasic effect on gastric ulceration, the ulcerogenic action is due to its alpha-action and antiulcerogenic effect is due to development of tachyphylaxis.
对大鼠肾上腺素诱导的胃溃疡进行了研究。高剂量肾上腺素可导致胃溃疡，预先用α受体阻滞剂（酚苄明、双苄胺）处理可完全阻断该溃疡形成，但预先用普萘洛尔或阿托品处理、迷走神经切断术、垂体切除术或肾上腺切除术均不能阻断。然而，连续7天每天给药一次肾上腺素后，未观察到胃溃疡。停药4周后，可见肾上腺素致溃疡作用恢复。小剂量肾上腺素预处理可抑制高剂量肾上腺素的致溃疡作用。利血平、焦性没食子酸或异烟肼预处理可抑制肾上腺素的作用。得出结论，肾上腺素对胃溃疡有双相作用，致溃疡作用归因于其α作用，抗溃疡作用归因于快速耐受性的产生。
