Izadpour Farrokh, Ranjbari Nastaran, Aramesh Mohammad-Reza, Moosavian Mojtaba, ShahAli Shiva, Larki Farzaneh, Tabesh Hamed, Morvaridi Afrooz
Health Research Institute, Infectious and Tropical Diseases Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, IR Iran.
Department of Pathology, Imam Khomeini Hospital, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, IR Iran.
Jundishapur J Microbiol. 2016 Aug 16;9(8):e35624. doi: 10.5812/jjm.35624. eCollection 2016 Aug.
In recent decades, multidrug-resistant non-fermenting Gram-negative pathogens, particularly and , have been recognized as a major cause of healthcare-associated and nosocomial infections and outbreaks.
The aim of this study was to determine the prevalence and pattern of antibiotic resistance in and isolates collected from intensive care units (ICUs).
One hundred fifty-five clinical isolates, including 80 (51.6%) isolates of and 75 (48.4%) isolates of , from hospitalized patients in the ICUs of a teaching hospital in Ahvaz, Iran, were collected from January 1 to December 30, 2013. The organisms were identified with conventional bacteriological methods, and antimicrobial susceptibility testing was performed on all isolates in accordance with clinical laboratory and standards institute (CLSI) guidelines.
The maximum resistance rates among isolates were observed for ciprofloxacin and trimethoprim-sulfamethoxazole (96.9% and 95.2%, respectively). For isolates, the maximum resistance rates were reported for ceftriaxone and trimethoprim-sulfamethoxazole (97.2% and 92.4%, respectively).
The majority of and isolates were found to be resistant to commonly recommended antibiotics. Therefore, surveillance of antibiotic consumption and proper antibiotic administration guidelines are essential for preventing major outbreaks in the future.
近几十年来，多重耐药的非发酵革兰氏阴性病原体，尤其是[具体病原体1]和[具体病原体2]，已被公认为医疗保健相关感染和医院感染及暴发的主要原因。
本研究旨在确定从重症监护病房（ICU）收集的[具体病原体1]和[具体病原体2]分离株中抗生素耐药性的流行情况和模式。
2013年1月1日至12月30日，从伊朗阿瓦士一家教学医院ICU的住院患者中收集了155株临床分离株，其中包括80株（51.6%）[具体病原体1]分离株和75株（48.4%）[具体病原体2]分离株。采用传统细菌学方法鉴定这些微生物，并根据临床实验室和标准协会（CLSI）指南对所有分离株进行药敏试验。
[具体病原体1]分离株中对环丙沙星和甲氧苄啶-磺胺甲恶唑的耐药率最高（分别为96.9%和95.2%）。对于[具体病原体2]分离株，头孢曲松和甲氧苄啶-磺胺甲恶唑的耐药率最高（分别为97.2%和92.4%）。
发现大多数[具体病原体1]和[具体病原体2]分离株对常用推荐抗生素耐药。因此，监测抗生素使用情况和制定适当的抗生素给药指南对于预防未来的重大疫情至关重要。
