伊朗鲍曼不动杆菌临床分离株中黏菌素敏感性的检测
Detection of colistin sensitivity in clinical isolates of Acinetobacter baumannii in Iran.
作者信息
Vakili Bahareh, Fazeli Hossein, Shoaei Parisa, Yaran Majid, Ataei Behrooz, Khorvash Farzin, Khaleghi Moj
机构信息
Department of Microbiology, Science and Research Branch, Islami Azad University, Kerman, Iran.
Infectious Diseases and Tropical Medicine Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
出版信息
J Res Med Sci. 2014 Mar;19(Suppl 1):S67-70.
BACKGROUND
Nosocomial infection caused by Acinetobacter baumannii has emerged as a serious problem world-wide. Finding the suitable drug is an important priority. The aim of this study was to determine colistin (polymyxin E) resistance in clinical isolates of A. baumannii from intensive care units (ICUs) of Al Zahra Hospital.
MATERIALS AND METHODS
Sixty isolates of A. baumannii from patients hospitalized in ICU (Al Zahra Hospital, Isfahan University of Medical Sciences [IUMS]) were studied. All isolates of A. baumannii were tested for colistin susceptibility by Eopsilometer test (E-test).
RESULTS
Of the 60 isolates 57, (95%) were multidrug resistant (MDR) and 76.6% (46/60) were highly resistant. The rate of colistin resistant with the E-test method was 11.6% (7/60).
CONCLUSION
As the frequency of resistance to colistin is low, it can be used as an easily available drug for treatment of MDR A. baumannii strains, which are susceptible to colistin.
背景
鲍曼不动杆菌引起的医院感染已成为全球范围内的一个严重问题。找到合适的药物是一项重要的优先任务。本研究的目的是确定来自伊斯法罕医科大学（IUMS）扎赫拉医院重症监护病房（ICU）的鲍曼不动杆菌临床分离株对黏菌素（多粘菌素E）的耐药性。
材料与方法
对扎赫拉医院（伊斯法罕医科大学）ICU住院患者的60株鲍曼不动杆菌分离株进行了研究。所有鲍曼不动杆菌分离株均通过Epsilometer试验（E试验）检测对黏菌素的敏感性。
结果
60株分离株中，57株（95%）为多重耐药（MDR），76.6%（46/60）为高度耐药。E试验法检测的黏菌素耐药率为11.6%（7/60）。
结论
由于对黏菌素的耐药频率较低，它可作为一种易于获得的药物，用于治疗对黏菌素敏感的多重耐药鲍曼不动杆菌菌株。
Zotero 插件