Watson C P, Evans R J, Watt V R
Smythe Pain Clinic, Toronto General Hospital, University of Toronto, Ont. Canada.
Pain. 1989 Aug;38(2):177-86. doi: 10.1016/0304-3959(89)90236-4.
Eighteen patients with the post-mastectomy pain syndrome (PMPS) form the basis of this study. PMPS probably occurs in a minority of women after mastectomy. The onset of persistent pain usually occurred immediately or very shortly after the operation. The pain location or sensory findings implied involvement of the territories of other cutaneous branches of the intercostal nerves as well as the intercostobrachial nerve. A variety of treatment approaches were unsatisfactory. Twelve of 14 patients completing treatment with topical 0.025% capsaicin showed improvement after 4 weeks and 8 (57%) were judged to be good or excellent responses. Six months after the trial's completion 50% of those followed continued to have good pain relief. This therapy should now be subjected to a randomized, double-blind, placebo-controlled trial.
18例患有乳房切除术后疼痛综合征（PMPS）的患者构成了本研究的基础。PMPS可能仅在少数乳房切除术后的女性中出现。持续性疼痛通常在手术后立即或很快就会出现。疼痛部位或感觉检查结果提示肋间神经的其他皮支以及肋间臂神经的分布区域均有累及。多种治疗方法效果均不理想。14例完成0.025%辣椒素局部治疗的患者中，12例在4周后症状有所改善，其中8例（57%）被判定为有良好或极佳的反应。试验结束6个月后，50%接受随访的患者仍有良好的疼痛缓解效果。现在应该对这种治疗方法进行随机、双盲、安慰剂对照试验。
