Watson Peter N C, Evans Ramon J
The Irene Eleanor Smythe Pain Clinic, Toronto General Hospital Toronto, Ontario M5G 2C4 Canada.
Pain. 1992 Dec;51(3):375-379. doi: 10.1016/0304-3959(92)90223-X.
This paper describes a randomized parallel trial of topical 0.075% capsaicin versus vehicle (placebo) in the postmastectomy pain syndrome (PMPS). The study was double-blind in design; however, this was compromised by the burning sensation induced by capsaicin. We could not demonstrate a significant difference in the visual analogue scale (VAS) for steady pain although a trend was present. A significant difference was found, however, in the VAS for jabbing pain, in category pain severity scales, and in overall pain relief scales in favour of capsaicin. Five of 13 patients on capsaicin were categorized as good-to-excellent responses with 8 (62%) having 50% or greater improvement. Only 1 of 10 cases had a good response to vehicle with 3 rated as 50% or better.
本文描述了一项针对乳房切除术后疼痛综合征（PMPS）患者的随机平行试验，比较局部使用0.075%辣椒素与赋形剂（安慰剂）的效果。该研究采用双盲设计；然而，由于辣椒素引起的灼烧感，这一设计受到了影响。尽管存在一定趋势，但我们未能证明在稳定疼痛的视觉模拟量表（VAS）上有显著差异。然而，在刺痛疼痛的VAS、类别疼痛严重程度量表以及总体疼痛缓解量表上，发现辣椒素组有显著差异。使用辣椒素的13名患者中有5名被归类为良好至优秀反应，其中8名（62%）改善了50%或更多。使用赋形剂的10例患者中只有1例有良好反应，3例改善了50%或更好。
