• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Improving the Pipeline for Developing and Testing Pharmacological Treatments in Pregnancy.改善孕期药物治疗研发与测试的流程。
PLoS Med. 2016 Nov 1;13(11):e1002161. doi: 10.1371/journal.pmed.1002161. eCollection 2016 Nov.
2
[Pharmacokinetic alterations in pregnancy and use of therapeutic drug monitoring].[妊娠期的药代动力学改变与治疗药物监测的应用]
Therapie. 2014 May-Jun;69(3):223-34. doi: 10.2515/therapie/2014026. Epub 2014 Jul 14.
3
Pregnancy-related pharmacokinetic changes.与妊娠相关的药代动力学变化。
Clin Pharmacol Ther. 2016 Jul;100(1):53-62. doi: 10.1002/cpt.382. Epub 2016 May 14.
4
Drug metabolism in pediatrics, pregnancy and lactation.
Curr Drug Metab. 2012 Jul;13(6):693. doi: 10.2174/138920012800840446.
5
Clinical relevance of therapeutic drug monitoring during pregnancy.
Ther Drug Monit. 2002 Feb;24(1):15-22. doi: 10.1097/00007691-200202000-00003.
6
Drug disposition: from cradle to cane.药物处置：从摇篮到拐杖。
Int J Pharm. 2013 Aug 16;452(1-2):1-2. doi: 10.1016/j.ijpharm.2013.05.035. Epub 2013 May 20.
7
Sex dependent pharmacokinetics and bioequivalence--time for a change.性别依赖性药代动力学与生物等效性——是时候做出改变了。
J Popul Ther Clin Pharmacol. 2013;20(3):e358-61. Epub 2013 Nov 6.
8
Research on pharmacokinetics during pregnancy.
Arch Toxicol Suppl. 1980;4:380-4. doi: 10.1007/978-3-642-67729-8_83.
9
Pharmacokinetic studies in pregnancy.妊娠期药代动力学研究。
Semin Perinatol. 2020 Apr;44(3):151227. doi: 10.1016/j.semperi.2020.151227. Epub 2020 Jan 27.
10
Pharmacokinetics during pregnancy and delivery.
Int J Biol Res Pregnancy. 1982;3(2):66-8.

引用本文的文献

1
Lipid-delivery system could treat life-threatening pregnancy complication.脂质递送系统可治疗危及生命的妊娠并发症。
Nature. 2025 Jan;637(8045):273-274. doi: 10.1038/d41586-024-03853-w.
2
The drug drought in maternal health: an ongoing predicament.孕产妇健康领域的药物短缺：一个持续存在的困境。
Lancet Glob Health. 2024 Jul;12(7):e1174-e1183. doi: 10.1016/S2214-109X(24)00144-X.
3
Genetic Associations of Circulating Cardiovascular Proteins With Gestational Hypertension and Preeclampsia.循环心血管蛋白与妊娠期高血压和子痫前期的遗传关联。
JAMA Cardiol. 2024 Mar 1;9(3):209-220. doi: 10.1001/jamacardio.2023.4994.
4
Rational Design of Nanomedicine for Placental Disorders: Birthing a New Era in Women's Reproductive Health.纳米医学治疗胎盘疾病的合理设计：开创女性生殖健康新时代。
Small. 2024 Oct;20(41):e2300852. doi: 10.1002/smll.202300852. Epub 2023 May 16.
5
Systematic evaluation of the pre-eclampsia drugs, dietary supplements and biologicals pipeline using target product profiles.运用目标产品特性，系统性评估子痫前期药物、膳食补充剂和生物制剂研发管线。
BMC Med. 2022 Nov 4;20(1):393. doi: 10.1186/s12916-022-02582-z.
6
Communication is crucial: Lessons from COVID-19 vaccination and pregnancy.沟通至关重要：COVID-19 疫苗接种和妊娠的经验教训。
Br J Clin Pharmacol. 2023 Feb;89(2):582-593. doi: 10.1111/bcp.15578. Epub 2022 Nov 24.
7
Innovations in the prevention and treatment of postpartum hemorrhage: Analysis of a novel medicines development pipeline database.创新的产后出血防治措施：新型药物研发管道数据库分析。
Int J Gynaecol Obstet. 2022 Jun;158 Suppl 1(Suppl 1):31-39. doi: 10.1002/ijgo.14200.
8
The immunobiology of preterm labor and birth: intra-amniotic inflammation or breakdown of maternal-fetal homeostasis.早产和分娩的免疫生物学：羊膜内炎症还是母婴内稳态的破坏。
Reproduction. 2022 Jun 20;164(2):R11-R45. doi: 10.1530/REP-22-0046.
9
A Review of Nanotechnology for Treating Dysfunctional Placenta.用于治疗胎盘功能障碍的纳米技术综述
Front Bioeng Biotechnol. 2022 Mar 24;10:845779. doi: 10.3389/fbioe.2022.845779. eCollection 2022.
10
Targeting the Dysfunctional Placenta to Improve Pregnancy Outcomes Based on Lessons Learned in Cancer.基于癌症领域的经验教训，靶向功能失调的胎盘以改善妊娠结局。
Clin Ther. 2021 Feb;43(2):246-264. doi: 10.1016/j.clinthera.2020.12.007. Epub 2021 Jan 11.

本文引用的文献

1
Pregnancy-Associated Changes in Pharmacokinetics: A Systematic Review.妊娠相关的药代动力学变化：一项系统评价。
PLoS Med. 2016 Nov 1;13(11):e1002160. doi: 10.1371/journal.pmed.1002160. eCollection 2016 Nov.
2
Paediatric Drug Development and Formulation Design-a European Perspective.儿科药物研发与制剂设计——欧洲视角
AAPS PharmSciTech. 2017 Feb;18(2):241-249. doi: 10.1208/s12249-016-0558-3. Epub 2016 Jun 7.
3
Preterm labor: current pharmacotherapy options for tocolysis.早产：目前用于保胎治疗的药物选择。
Expert Opin Pharmacother. 2014 Apr;15(6):787-97. doi: 10.1517/14656566.2014.889684. Epub 2014 Feb 17.
4
The role of teratology information services in screening for teratogenic exposures: challenges and opportunities.畸形学信息服务在致畸暴露筛查中的作用：挑战与机遇。
Am J Med Genet C Semin Med Genet. 2011 Aug 15;157C(3):195-200. doi: 10.1002/ajmg.c.30303. Epub 2011 Jul 11.
5
The long-term effects of in utero exposures--the DES story.子宫内暴露的长期影响——己烯雌酚的故事。
N Engl J Med. 2011 Jun 2;364(22):2083-4. doi: 10.1056/NEJMp1104409. Epub 2011 Apr 20.
6
Off-label prescribing during pregnancy in the UK: an analysis of 18,000 prescriptions in Liverpool Women's Hospital.英国孕期超说明书用药情况：对利物浦妇女医院18000份处方的分析
Int J Pharm Pract. 2010 Aug;18(4):226-9. doi: 10.1211/ijpp.18.04.0007.
7
Thalidomide induces limb defects by preventing angiogenic outgrowth during early limb formation.沙利度胺通过在肢体早期形成过程中阻止血管生成性生长而导致肢体缺陷。
Proc Natl Acad Sci U S A. 2009 May 26;106(21):8573-8. doi: 10.1073/pnas.0901505106. Epub 2009 May 11.
8
Market failure and the poverty of new drugs in maternal health.市场失灵与孕产妇保健新药匮乏
PLoS Med. 2008 Jan 22;5(1):e22. doi: 10.1371/journal.pmed.0050022.
9
Prescription, over-the-counter, and herbal medicine use in a rural, obstetric population.农村产科人群的处方药、非处方药及草药使用情况。
Am J Obstet Gynecol. 2003 Apr;188(4):1039-45. doi: 10.1067/mob.2003.223.
10
Fetal programming and adult health.胎儿编程与成人健康。
Public Health Nutr. 2001 Apr;4(2B):611-24. doi: 10.1079/phn2001145.

改善孕期药物治疗研发与测试的流程。

Improving the Pipeline for Developing and Testing Pharmacological Treatments in Pregnancy.

作者信息

Chappell Lucy C, David Anna L

机构信息

Women's Health Academic Centre, King's College London, London, United Kingdom.

Institute for Women's Health, University College London, London, United Kingdom.

出版信息

PLoS Med. 2016 Nov 1;13(11):e1002161. doi: 10.1371/journal.pmed.1002161. eCollection 2016 Nov.

DOI:10.1371/journal.pmed.1002161
PMID:27802279
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5089678/
Abstract

In a Perspective, Lucy Chappell and Anna David discuss ways to develop and test pharmacological treatments in pregnancy.

摘要

露西·查佩尔和安娜·大卫在一篇《观点》文章中讨论了开发和测试孕期药物治疗方法的途径。