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Different 3'-end processing produces two independently regulated mRNAs from a single H1 histone gene.

作者信息

Cheng G H, Nandi A, Clerk S, Skoultchi A I

机构信息

Department of Cell Biology, Albert Einstein College of Medicine, Bronx, NY 10461.

出版信息

Proc Natl Acad Sci U S A. 1989 Sep;86(18):7002-6. doi: 10.1073/pnas.86.18.7002.

DOI:10.1073/pnas.86.18.7002
PMID:2780558
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC297980/
Abstract

We describe the isolation of a mouse H1 histone gene that encodes two mRNA transcripts. One mRNA ends just beyond the coding region, near a highly conserved palindrome sequence typical of cell cycle-regulated histone genes. The level of this transcript is coupled to DNA replication. The second mRNA ends nearly 1 kilobase downstream near a polyadenylation signal. This mRNA is polyadenylylated, and its accumulation is not coupled to DNA replication. The two mRNAs are regulated independently and in some circumstances in opposite directions under several physiological conditions. The production of a polyadenylylated mRNA from an otherwise cell cycle-regulated histone gene may allow for continued synthesis of the histone protein when DNA synthesis ceases in nondividing cells.

摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/177a/297980/aa70b8b5009e/pnas00285-0184-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/177a/297980/6aa65f90e655/pnas00285-0182-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/177a/297980/4d6c91097b39/pnas00285-0183-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/177a/297980/b369ecc621d7/pnas00285-0184-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/177a/297980/aa70b8b5009e/pnas00285-0184-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/177a/297980/6aa65f90e655/pnas00285-0182-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/177a/297980/4d6c91097b39/pnas00285-0183-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/177a/297980/b369ecc621d7/pnas00285-0184-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/177a/297980/aa70b8b5009e/pnas00285-0184-b.jpg

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Proc Natl Acad Sci U S A. 1989 Sep;86(18):7002-6. doi: 10.1073/pnas.86.18.7002.
2
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4
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A human histone H2B.1 variant gene, located on chromosome 1, utilizes alternative 3' end processing.一个位于1号染色体上的人类组蛋白H2B.1变体基因利用了可变的3'末端加工。
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Regulation of human histone gene expression: transcriptional and posttranscriptional control in the coupling of histone messenger RNA stability with DNA replication.人类组蛋白基因表达的调控：组蛋白信使核糖核酸稳定性与DNA复制偶联中的转录和转录后控制
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本文引用的文献

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Histone H5 messenger RNA is polyadenylated.组蛋白H5信使核糖核酸是聚腺苷酸化的。
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The histone H1 complements of dividing and nondividing cells of the mouse.小鼠分裂细胞和非分裂细胞的组蛋白H1互补物。
sCLIP——生物医学研究中用于研究RNA-蛋白质相互作用组的集成平台：小核RNA可变加工中CSTF2tau的鉴定
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A subset of replication-dependent histone mRNAs are expressed as polyadenylated RNAs in terminally differentiated tissues.一部分依赖复制的组蛋白mRNA在终末分化组织中以多聚腺苷酸化RNA的形式表达。
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Role of H1 linker histones in mammalian development and stem cell differentiation.H1连接组蛋白在哺乳动物发育和干细胞分化中的作用。
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PPS: A computing engine to find Palindromes in all Protein sequences.PPS：一种在所有蛋白质序列中查找回文序列的计算引擎。
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An algorithm to find all palindromic sequences in proteins.一种在蛋白质中寻找所有回文序列的算法。
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H1 linker histone promotes epigenetic silencing by regulating both DNA methylation and histone H3 methylation.H1 连接组蛋白通过调节 DNA 甲基化和组蛋白 H3 甲基化促进表观遗传沉默。
Proc Natl Acad Sci U S A. 2013 Jan 29;110(5):1708-13. doi: 10.1073/pnas.1213266110. Epub 2013 Jan 9.
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Early evolution of histone genes: prevalence of an 'orphon' H1 lineage in protostomes and birth-and-death process in the H2A family.组蛋白基因的早期进化：原口动物中“孤儿”H1谱系的普遍性以及H2A家族中的生死过程。
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Early evolution of histone mRNA 3' end processing.组蛋白mRNA 3'末端加工的早期进化。
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Organization and expression of eucaryotic split genes coding for proteins.编码蛋白质的真核生物断裂基因的组织与表达。
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Requirement of a downstream sequence for generation of a poly(A) addition site.生成聚腺苷酸化位点对下游序列的要求。
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Regulation of histone mRNA production and stability in serum-stimulated mouse 3T6 fibroblasts.血清刺激的小鼠3T6成纤维细胞中组蛋白mRNA产生和稳定性的调控
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3' editing of mRNAs: sequence requirements and involvement of a 60-nucleotide RNA in maturation of histone mRNA precursors.信使核糖核酸的3'端编辑：序列要求及一段60个核苷酸的核糖核酸在组蛋白信使核糖核酸前体成熟过程中的作用
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Histone mRNA concentrations are regulated at the level of transcription and mRNA degradation.组蛋白mRNA的浓度在转录和mRNA降解水平上受到调控。
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9
Regulation of human histone gene expression: kinetics of accumulation and changes in the rate of synthesis and in the half-lives of individual histone mRNAs during the HeLa cell cycle.人类组蛋白基因表达的调控：海拉细胞周期中组蛋白mRNA的积累动力学、合成速率变化及各个组蛋白mRNA半衰期的变化
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The terminal RNA stem-loop structure and 80 bp of spacer DNA are required for the formation of 3' termini of sea urchin H2A mRNA.海胆H2A mRNA 3'末端的形成需要末端RNA茎环结构和80个碱基对的间隔DNA。
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