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在灵长类前额皮质中，多巴胺 D1 受体对靶标和干扰物的细胞类型特异性调节。

Cell-type-specific modulation of targets and distractors by dopamine D1 receptors in primate prefrontal cortex.

机构信息

Department of Animal Physiology, Institute of Neurobiology, Eberhard-Karls-Universität Tübingen, Auf der Morgenstelle 28, 72076 Tübingen, Germany.

出版信息

Nat Commun. 2016 Oct 27;7:13218. doi: 10.1038/ncomms13218.

DOI:10.1038/ncomms13218
PMID:27807366
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5095292/
Abstract

The prefrontal cortex (PFC) is crucial for maintaining relevant information in working memory and resisting interference. PFC neurons are strongly regulated by dopamine, but it is unknown whether dopamine receptors are involved in protecting target memories from distracting stimuli. We investigated the prefrontal circuit dynamics and dopaminergic modulation of targets and distractors in monkeys trained to ignore interfering stimuli in a delayed-match-to-numerosity task. We found that dopamine D1 receptors (D1Rs) modulate the recovery of task-relevant information following a distracting stimulus. The direction of modulation is cell-type-specific: in putative pyramidal neurons, D1R inhibition enhances and D1R stimulation attenuates coding of the target stimulus after the interference, while the opposite pattern is observed in putative interneurons. Our results suggest that dopaminergic neuromodulation of PFC circuits regulates mental representations of behaviourally relevant stimuli that compete with task-irrelevant input and could play a central role for cognitive functioning in health and disease.

摘要

前额皮质（PFC）对于在工作记忆中保持相关信息和抵抗干扰至关重要。PFC 神经元受到多巴胺的强烈调节，但尚不清楚多巴胺受体是否参与保护目标记忆免受干扰刺激的影响。我们研究了猴子在延迟匹配到数量任务中被训练忽略干扰刺激时，前额叶回路动力学和多巴胺能调制目标和干扰物的情况。我们发现多巴胺 D1 受体（D1R）调节在干扰后与任务相关信息的恢复。调制的方向是细胞类型特异性的：在推测的锥体神经元中，D1R 抑制增强，D1R 刺激减弱干扰后目标刺激的编码，而在推测的中间神经元中则观察到相反的模式。我们的结果表明，PFC 回路的多巴胺能神经调制调节了与行为相关刺激的心理表征，这些刺激与任务不相关的输入竞争，可能在健康和疾病中的认知功能中发挥核心作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b35c/5095292/d029140cf65d/ncomms13218-f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b35c/5095292/30c9f899593a/ncomms13218-f1.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b35c/5095292/88cc15cdfb4b/ncomms13218-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b35c/5095292/f5eee7fadf0a/ncomms13218-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b35c/5095292/7b712963811d/ncomms13218-f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b35c/5095292/d029140cf65d/ncomms13218-f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b35c/5095292/30c9f899593a/ncomms13218-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b35c/5095292/977061d63104/ncomms13218-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b35c/5095292/21953af06c37/ncomms13218-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b35c/5095292/88cc15cdfb4b/ncomms13218-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b35c/5095292/f5eee7fadf0a/ncomms13218-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b35c/5095292/7b712963811d/ncomms13218-f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b35c/5095292/d029140cf65d/ncomms13218-f7.jpg

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